Mortality in Inflammatory Rheumatic Diseases: Lithuanian National Registry Data and Systematic Review

Jolanta Dadonienė, Greta Charukevič, Gabija Jasionytė, Karolina Staškuvienė and Dalia Miltinienė
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Jolanta Dadonienė: State Research Institute Centre for Innovative Medicine, LT-08406 Vilnius, Lithuania
Greta Charukevič: Department of Public Health, Institute of Health Sciences, Vilnius University Faculty of Medicine, LT-03101 Vilnius, Lithuania
Gabija Jasionytė: Clinic of Rheumatology, Orthopaedics Traumatology and Reconstructive Surgery, Institute of Clinical Medicine, Vilnius University Faculty of Medicine, LT-03101 Vilnius, Lithuania
Karolina Staškuvienė: Clinic of Rheumatology, Orthopaedics Traumatology and Reconstructive Surgery, Institute of Clinical Medicine, Vilnius University Faculty of Medicine, LT-03101 Vilnius, Lithuania
Dalia Miltinienė: State Research Institute Centre for Innovative Medicine, LT-08406 Vilnius, Lithuania

IJERPH, 2021, vol. 18, issue 23, 1-13

Abstract: Despite significant improvement in survival, rheumatic diseases (RD) are associated with premature mortality rates comparable to cardiovascular and neoplastic disorders. The aim of our study was to assess mortality, causes of death, and life expectancy in an inflammatory RD retrospective cohort and compare those with the general population as well as with the results of previously published studies in a systematic literature review. Patients with the first-time diagnosis of inflammatory RD during 2012–2019 were identified and cross-checked for their vital status and the date of death. Sex- and age-standardized mortality ratios (SMR) as well as life expectancy for patients with inflammatory RDs were calculated. The results of a systematic literature review were included in meta-standardized mortality ratio calculations. 11,636 patients with newly diagnosed RD were identified. During a total of 43,064.34 person-years of follow-up, 950 death cases occurred. The prevailing causes of death for the total cohort were cardiovascular diseases and neoplasms. The age- and sex-adjusted SMR for the total cohort was calculated to be 1.32 (1.23; 1.40). Patients with rheumatoid arthritis if diagnosed at age 18–19 tend to live for 1.63 years less than the general population, patients with spondyloarthritis—for 2.7 years less, patients with connective tissue diseases—for almost nine years less than the general population. The findings of our study support the hypothesis that patients with RD have a higher risk of mortality and lower life expectancy than the general population.

Keywords: rheumatic diseases; mortality; standardized mortality ratio; life expectancy; systematic review (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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