In Vitro Recapitulation of Neuropsychiatric Disorders with Pluripotent Stem Cells-Derived Brain Organoids

Maisumu Gulimiheranmu, Shuang Li and Junmei Zhou
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Maisumu Gulimiheranmu: Department of Central Laboratory, Shanghai Children’s Hospital, Shanghai Jiao Tong University, 1400 Beijing Road West, Shanghai 200040, China
Shuang Li: Department of Central Laboratory, Shanghai Children’s Hospital, Shanghai Jiao Tong University, 1400 Beijing Road West, Shanghai 200040, China
Junmei Zhou: Department of Central Laboratory, Shanghai Children’s Hospital, Shanghai Jiao Tong University, 1400 Beijing Road West, Shanghai 200040, China

IJERPH, 2021, vol. 18, issue 23, 1-14

Abstract: Adolescent neuropsychiatric disorders have been recently increasing due to genetic and environmental influences. Abnormal brain development before and after birth contribute to the pathology of neuropsychiatric disorders. However, it is difficult to experimentally investigate because of the complexity of brain and ethical constraints. Recently generated human brain organoids from pluripotent stem cells are considered as a promising in vitro model to recapitulate brain development and diseases. To better understand how brain organoids could be applied to investigate neuropsychiatric disorders, we analyzed the key consideration points, including how to generate brain organoids from pluripotent stem cells, the current application of brain organoids in recapitulating neuropsychiatric disorders and the future perspectives. This review covered what have been achieved on modeling the cellular and neural circuit deficits of neuropsychiatric disorders and those challenges yet to be solved. Together, this review aims to provide a fundamental understanding of how to generate brain organoids to model neuropsychiatric disorders, which will be helpful in improving the mental health of adolescents.

Keywords: brain organoid induction; adolescent neuropsychiatric disorders; autism spectrum disorders (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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