The Impact of Clinical, Biochemical, and Echocardiographic Parameters on the Quality of Life in Patients with Heart Failure with Reduced Ejection Fraction

Marta Kałużna-Oleksy, Filip Sawczak, Agata Kukfisz, Helena Krysztofiak, Magdalena Szczechla, Marta Wleklik, Katarzyna Przytarska, Magdalena Dudek, Alicja Nowak, Ewa Straburzyńska-Migaj and Bartosz Uchmanowicz
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Marta Kałużna-Oleksy: 1st Department of Cardiology, University of Medical Sciences in Poznan, 61-848 Poznan, Poland
Filip Sawczak: 1st Department of Cardiology, University of Medical Sciences in Poznan, 61-848 Poznan, Poland
Agata Kukfisz: 1st Department of Cardiology, University of Medical Sciences in Poznan, 61-848 Poznan, Poland
Helena Krysztofiak: 1st Department of Cardiology, University of Medical Sciences in Poznan, 61-848 Poznan, Poland
Magdalena Szczechla: 1st Department of Cardiology, University of Medical Sciences in Poznan, 61-848 Poznan, Poland
Marta Wleklik: Faculty of Health Sciences, Wroclaw Medical University, 50-367 Wroclaw, Poland
Katarzyna Przytarska: 1st Department of Cardiology, University of Medical Sciences in Poznan, 61-848 Poznan, Poland
Magdalena Dudek: 1st Department of Cardiology, University of Medical Sciences in Poznan, 61-848 Poznan, Poland
Alicja Nowak: 1st Department of Cardiology, University of Medical Sciences in Poznan, 61-848 Poznan, Poland
Ewa Straburzyńska-Migaj: 1st Department of Cardiology, University of Medical Sciences in Poznan, 61-848 Poznan, Poland
Bartosz Uchmanowicz: Faculty of Health Sciences, Wroclaw Medical University, 50-367 Wroclaw, Poland

IJERPH, 2021, vol. 18, issue 23, 1-14

Abstract: Despite significant advances in HF diagnosis and treatment over the recent decades, patients still characterize poor long-term prognosis with many recurrent hospitalizations and reduced health-related quality of life (HRQoL). We aimed to check the potential relationship between clinical, biochemical, or echocardiographic parameters and HRQoL in patients with HF with reduced ejection fraction (HFrEF). We included 152 adult patients hospitalized due to chronic HFrEF. We used the WHOQoL-BREF questionnaire to assess HRQoL and GNRI to evaluate nutritional status. We also analyzed several biochemical parameters and left ventricle ejection fraction. Forty (26.3%) patients were hospitalized due to HF exacerbation and 112 (73.7%) due to planned HF evaluation. The median age was 57 (48–62) years. Patients with low somatic HRQoL score had lower transferrin saturation (23.7 ± 11.1 vs. 29.7 ± 12.5%; p = 0.01), LDL (2.40 (1.80–2.92) vs. 2.99 (2.38–3.60) mmol/L; p = 0.001), triglycerides (1.18 (0.91–1.57) vs. 1.48 (1.27–2.13) mmol/L; p = 0.006) and LVEF (20 (15–25) vs. 25 (20–30)%; p = 0.003). TIBC (64.9 (58.5–68.2) vs. 57.7 (52.7–68.6); p = 0.02) was significantly higher in this group. We observed no associations between HRQoL and age or gender. The somatic domain of WHOQoL-BREF in patients with HFrEF correlated with the clinical status as well as biochemical and echocardiographic parameters. Assessment of HRQoL in HFrEF seems important in everyday practice and can identify patients requiring a special intervention

Keywords: quality of life; health-related quality of life; heart failure; heart failure with reduced ejection fraction (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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