Developing a Stacked Ensemble-Based Classification Scheme to Predict Second Primary Cancers in Head and Neck Cancer Survivors

Chi-Chang Chang, Tse-Hung Huang, Pei-Wei Shueng, Ssu-Han Chen, Chun-Chia Chen, Chi-Jie Lu and Yi-Ju Tseng
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Chi-Chang Chang: School of Medical Informatics, Chung Shan Medical University & IT Office, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
Tse-Hung Huang: Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Keelung 20401, Taiwan
Pei-Wei Shueng: Department of Radiology, Division of Radiation Oncology, Far Eastern Memorial Hospital, New Taipei 22060, Taiwan
Ssu-Han Chen: Department of Industrial Engineering and Management, Ming Chi University of Technology, New Taipei 24330, Taiwan
Chun-Chia Chen: Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
Chi-Jie Lu: Graduate Institute of Business Administration, Fu Jen Catholic University, New Taipei 242062, Taiwan
Yi-Ju Tseng: Department of Information Management, National Central University, Taoyuan 32031, Taiwan

IJERPH, 2021, vol. 18, issue 23, 1-10

Abstract: Despite a considerable expansion in the present therapeutic repertoire for other malignancy managements, mortality from head and neck cancer (HNC) has not significantly improved in recent decades. Moreover, the second primary cancer (SPC) diagnoses increased in patients with HNC, but studies providing evidence to support SPCs prediction in HNC are lacking. Several base classifiers are integrated forming an ensemble meta-classifier using a stacked ensemble method to predict SPCs and find out relevant risk features in patients with HNC. The balanced accuracy and area under the curve (AUC) are over 0.761 and 0.847, with an approximately 2% and 3% increase, respectively, compared to the best individual base classifier. Our study found the top six ensemble risk features, such as body mass index, primary site of HNC, clinical nodal (N) status, primary site surgical margins, sex, and pathologic nodal (N) status. This will help clinicians screen HNC survivors before SPCs occur.

Keywords: head and neck cancer; stacked ensemble-based classification scheme; risk prediction; second primary cancers (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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