Current Thoughts of Notch’s Role in Myoblast Regulation and Muscle-Associated Disease

Jeffrey C. Gerrard, Jamison P. Hay, Ryan N. Adams, James C. Williams, Joshua R. Huot, Kaitlin M. Weathers, Joseph S. Marino and Susan T. Arthur
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Jeffrey C. Gerrard: Department of Applied Physiology, Health and Clinical Sciences, University of North Carolina-Charlotte, Charlotte, NC 28223, USA
Jamison P. Hay: Department of Applied Physiology, Health and Clinical Sciences, University of North Carolina-Charlotte, Charlotte, NC 28223, USA
Ryan N. Adams: Department of Applied Physiology, Health and Clinical Sciences, University of North Carolina-Charlotte, Charlotte, NC 28223, USA
James C. Williams: Department of Applied Physiology, Health and Clinical Sciences, University of North Carolina-Charlotte, Charlotte, NC 28223, USA
Joshua R. Huot: Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Kaitlin M. Weathers: Department of Applied Physiology, Health and Clinical Sciences, University of North Carolina-Charlotte, Charlotte, NC 28223, USA
Joseph S. Marino: Department of Applied Physiology, Health and Clinical Sciences, University of North Carolina-Charlotte, Charlotte, NC 28223, USA
Susan T. Arthur: Department of Applied Physiology, Health and Clinical Sciences, University of North Carolina-Charlotte, Charlotte, NC 28223, USA

IJERPH, 2021, vol. 18, issue 23, 1-20

Abstract: The evolutionarily conserved signaling pathway Notch is unequivocally essential for embryogenesis. Notch’s contribution to the muscle repair process in adult tissue is complex and obscure but necessary. Notch integrates with other signals in a functional antagonist manner to direct myoblast activity and ultimately complete muscle repair. There is profound recent evidence describing plausible mechanisms of Notch in muscle repair. However, the story is not definitive as evidence is slowly emerging that negates Notch’s importance in myoblast proliferation. The purpose of this review article is to examine the prominent evidence and associated mechanisms of Notch’s contribution to the myogenic repair phases. In addition, we discuss the emerging roles of Notch in diseases associated with muscle atrophy. Understanding the mechanisms of Notch’s orchestration is useful for developing therapeutic targets for disease.

Keywords: Hes1; satellite cells; cachexia; Pax7; muscle repair; Wnt; mTOR (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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