Factors Associated with Unfavourable Treatment Outcomes in Patients with Tuberculosis: A 16-Year Cohort Study (2005–2020), Republic of Karakalpakstan, Uzbekistan

Jamshid Gadoev, Damin Asadov, Anthony D. Harries, Ajay M. V. Kumar, Martin Johan Boeree, Araksya Hovhannesyan, Lianne Kuppens, Askar Yedilbayev, Oleksandr Korotych, Atadjan Hamraev, Kallibek Kudaybergenov, Barno Abdusamatova, Bakhtinur Khudanov and Masoud Dara
Additional contact information
Jamshid Gadoev: WHO Country Office in Uzbekistan, 16-Tarobiy, Tashkent 100100, Uzbekistan
Damin Asadov: Center of Development of Professional Qualification of Medical Personnel, Tashkent 100007, Uzbekistan
Anthony D. Harries: Centre for Operational Research, International Union Against Tuberculosis and Lung Disease, 2 Rue Jean Lantier, 75001 Paris, France
Ajay M. V. Kumar: Centre for Operational Research, International Union Against Tuberculosis and Lung Disease, 2 Rue Jean Lantier, 75001 Paris, France
Martin Johan Boeree: Department of Lung Diseases, Radboudumc, 6500 HB Nijmegen/TB Expert Centre Dekkerswald, 6561KE Groesbeek, The Netherlands
Araksya Hovhannesyan: World Health Organization Regional Office for Europe, UN City, Marmorvej 51, DK-2100 Copenhagen, Denmark
Lianne Kuppens: WHO Country Office in Uzbekistan, 16-Tarobiy, Tashkent 100100, Uzbekistan
Askar Yedilbayev: World Health Organization Regional Office for Europe, UN City, Marmorvej 51, DK-2100 Copenhagen, Denmark
Oleksandr Korotych: World Health Organization Regional Office for Europe, UN City, Marmorvej 51, DK-2100 Copenhagen, Denmark
Atadjan Hamraev: Center of Development of Professional Qualification of Medical Personnel, Tashkent 100007, Uzbekistan
Kallibek Kudaybergenov: Republican Phthisiology and Pulmonology Center Named after Sultanov, Nukus 1735401, Republic of Karakalpakstan
Barno Abdusamatova: Ministry of Health of Republic of Uzbekistan, Tashkent 100011, Uzbekistan
Bakhtinur Khudanov: Ministry of Health of Republic of Uzbekistan, Tashkent 100011, Uzbekistan
Masoud Dara: World Health Organization Regional Office for Europe, UN City, Marmorvej 51, DK-2100 Copenhagen, Denmark

IJERPH, 2021, vol. 18, issue 23, 1-19

Abstract: Tuberculosis (TB) remains a public health burden in the Republic of Karakalpakstan, Uzbekistan. This region-wide retrospective cohort study reports the treatment outcomes of patients registered in the TB electronic register and treated with first-line drugs in the TB Programme of the Republic of Karakalpakstan from 2005–2020 and factors associated with unfavourable outcomes. Among 35,122 registered patients, 24,394 (69%) patients were adults, 2339 (7%) were children, 18,032 (51%) were male and 19,774 (68%) lived in rural areas. Of these patients, 29,130 (83%) had pulmonary TB and 7497 (>22%) had been previously treated. There were 7440 (21%) patients who had unfavourable treatment outcomes. Factors associated with unfavourable treatment outcomes included: increasing age, living in certain parts of the republic, disability, pensioner status, unemployment, being HIV-positive, having pulmonary TB, and receiving category II treatment. Factors associated with death included: being adult and elderly, living in certain parts of the republic, having a disability, pensioner status, being HIV-positive, and receiving category II treatment. Factors associated with failure included: being adolescent, female, having pulmonary TB. Factors associated with loss to follow-up included: being male, disability, pensioner status, unemployment, receiving category II treatment. In summary, there are sub-groups of patients who need special attention in order to decrease unfavourable treatment outcomes.

Keywords: tuberculosis; unfavourable treatment outcomes; central Asia; Republic of Uzbekistan; Republic of Karakalpakstan; drug resistant tuberculosis; death; failure; loss to follow up; transfer out (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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