Sudden Unexpected Death Caused by Cardiac Metastasization from Histiocytic Sarcoma

Alessandro Feola, Paola Ciamarra, Mariavictoria De Simone, Anna Carfora, Gelsomina Mansueto and Carlo Pietro Campobasso
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Alessandro Feola: Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Paola Ciamarra: Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Mariavictoria De Simone: Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Anna Carfora: Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Gelsomina Mansueto: Department of Advanced Medical and Surgical Sciences (DAMSS), University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Carlo Pietro Campobasso: Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy

IJERPH, 2021, vol. 18, issue 24, 1-6

Abstract: Background: Haematological malignancies, such as lymphoma and leukaemia, can have a variety of clinical manifestations. The most frequent cause of death from haematological malignancies is multiple organ failure due to neoplastic organ infiltration and/or septic shock. Histiocytic sarcoma (HS) is a rare malignant nodal or extranodal tumour with histiocytic immunophenotype that originates from a lymphohematopoietic precursor. The patients with HS usually have a poor prognosis due to its aggressive clinical behaviour. Rare cases of undiagnosed sudden HS death have been described in the literature. Methods: A forensic autopsy of a 46-year-old white male who died at home suddenly and unexpectedly without warning conditions or known diseases. Gross analysis, histology and toxicology were also performed. Results: The diagnosis of HS of the ileum with secondary nodal and cardiac metastatization was made. Conclusions: A prompt diagnosis of HS in life is paramount because it can make a difference in prognostic outcomes.

Keywords: haematological malignancies; lymphoma; leukaemia; histiocytic sarcoma; sudden death; autopsy; arrhythmia; myocarditis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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