Drug–Drug Interactions in Vestibular Diseases, Clinical Problems, and Medico-Legal Implications

Giulio Di Mizio, Gianmarco Marcianò, Caterina Palleria, Lucia Muraca, Vincenzo Rania, Roberta Roberti, Giuseppe Spaziano, Amalia Piscopo, Valeria Ciconte, Nunzio Di Nunno, Massimiliano Esposito, Pasquale Viola, Davide Pisani, Giovambattista De Sarro, Milena Raffi, Alessandro Piras, Giuseppe Chiarella and Luca Gallelli
Additional contact information
Giulio Di Mizio: Department of Law, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy
Gianmarco Marcianò: Department of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini Hospital, 88100 Catanzaro, Italy
Caterina Palleria: Department of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini Hospital, 88100 Catanzaro, Italy
Lucia Muraca: Department of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini Hospital, 88100 Catanzaro, Italy
Vincenzo Rania: Department of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini Hospital, 88100 Catanzaro, Italy
Roberta Roberti: Department of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini Hospital, 88100 Catanzaro, Italy
Giuseppe Spaziano: Department of Experimental Medicine L. Donatelli, Section of Pharmacology, School of Medicine, University of Campania Luigi Vanvitelli, 80123 Naples, Italy
Amalia Piscopo: Department of Law, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy
Valeria Ciconte: Department of Law, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy
Nunzio Di Nunno: Department of History, Society and Studies on Humanity, University of Salento, 83100 Lecce, Italy
Massimiliano Esposito: Department of Medical, Surgical Sciences and Advanced Technologies “G. F. Ingrassia”, University of Catania, 95121 Catania, Italy
Pasquale Viola: Unit of Audiology, Department of Experimental and Clinical Medicine, Regional Centre of Cochlear Implants and ENT Diseases, Magna Graecia University, 88100 Catanzaro, Italy
Davide Pisani: Unit of Audiology, Department of Experimental and Clinical Medicine, Regional Centre of Cochlear Implants and ENT Diseases, Magna Graecia University, 88100 Catanzaro, Italy
Giovambattista De Sarro: Department of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini Hospital, 88100 Catanzaro, Italy
Milena Raffi: Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy
Alessandro Piras: Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy
Giuseppe Chiarella: Unit of Audiology, Department of Experimental and Clinical Medicine, Regional Centre of Cochlear Implants and ENT Diseases, Magna Graecia University, 88100 Catanzaro, Italy
Luca Gallelli: Department of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini Hospital, 88100 Catanzaro, Italy

IJERPH, 2021, vol. 18, issue 24, 1-42

Abstract: Peripheral vestibular disease can be treated with several approaches (e.g., maneuvers, surgery, or medical approach). Comorbidity is common in elderly patients, so polytherapy is used, but it can generate the development of drug–drug interactions (DDIs) that play a role in both adverse drug reactions and reduced adherence. For this reason, they need a complex kind of approach, considering all their individual characteristics. Physicians must be able to prescribe and deprescribe drugs based on a solid knowledge of pharmacokinetics, pharmacodynamics, and clinical indications. Moreover, full information is required to reach a real therapeutic alliance, to improve the safety of care and reduce possible malpractice claims related to drug–drug interactions. In this review, using PubMed, Embase, and Cochrane library, we searched articles published until 30 August 2021, and described both pharmacokinetic and pharmacodynamic DDIs in patients with vestibular disorders, focusing the interest on their clinical implications and on risk management strategies.

Keywords: polytherapy; elderly; vestibular disease; vertigo; drug interactions; clinical practice; clinical risk management; safety of care; medico legal aspects (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/18/24/12936/pdf (application/pdf)
https://www.mdpi.com/1660-4601/18/24/12936/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:18:y:2021:i:24:p:12936-:d:697614

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().