Effect of WW Domain-Containing Oxidoreductase Gene Polymorphism on Clinicopathological Characteristics of Patients with EGFR Mutant Lung Adenocarcinoma in Taiwan

Ju-Pi Li, Jinghua Tsai Chang, Po-Chung Ju, Ming-Hong Hsieh, Yu-Hua Chao, Thomas Chang-Yao Tsao, Ming-Ju Hsieh and Shun-Fa Yang
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Ju-Pi Li: School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Jinghua Tsai Chang: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Po-Chung Ju: School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Ming-Hong Hsieh: School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Yu-Hua Chao: School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Thomas Chang-Yao Tsao: School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Ming-Ju Hsieh: Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan
Shun-Fa Yang: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan

IJERPH, 2021, vol. 18, issue 24, 1-10

Abstract: Lung adenocarcinoma is the most common histological type of non-small cell lung cancer, which accounts for the majority of lung cancers. Previous studies have showed that dysregulation of WW domain-containing oxidoreductase ( WWOX ) participates in the generation of several cancer types, including lung cancer. However, whether these WWOX polymorphisms are related to the clinical risk of epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma is worthy of investigation. The present study examined the relationship between the WWOX single-nucleotide polymorphisms (SNPs; rs11545028, rs12918952, rs3764340, rs73569323, and rs383362) and the clinicopathological factors in lung adenocarcinoma patients with or without EGFR mutations. We found that there was no significant difference in the genotype distribution of WWOX polymorphism between EGFR wild-type and EGFR mutant in patients with lung adenocarcinoma. Our results demonstrated that the presence of at least one G genotype (CG and GG) allele on WWOX rs3764340 was associated with a significantly higher risk of nearby lymph node involvement in those patients harboring EGFR mutations (odds ratio (OR) = 3.881, p = 0.010) compared with the CC genotype. Furthermore, in the subgroup of lung adenocarcinoma patients with the EGFR-L858R mutation, both WWOX rs3764340 C/G (OR = 5.209, p = 0.023) and rs73569323 C/T polymorphisms (OR = 3.886, p = 0.039) exhibited significant associations with the size of primary tumors and the invasion of adjacent tissues. In conclusion, these data indicate that WWOX SNPs may help predict tumor growth and invasion in patients with EGFR mutant lung adenocarcinoma, especially those with the EGFR-L858R mutant in Taiwan.

Keywords: lung cancer; WWOX; polymorphism; EGFR mutation (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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