Is Isocyanate Exposure and Occupational Asthma Still a Major Occupational Health Concern? Systematic Literature Review

Elie Coureau, Luc Fontana, Céline Lamouroux, Carole Pélissier and Barbara Charbotel
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Elie Coureau: UMRESTTE, UMR T 9405, Université Lyon 1, Université Gustave Eiffel—IFSTTAR, Domaine Rockefeller, 8 Avenue Rockefeller, 69008 Lyon, France
Luc Fontana: Hospital University Center of Saint-Etienne, Université Lyon 1, Université de St Etienne, IFSTTAR, UMRESTTE, UMR T 9405, 42005 Saint-Etienne, France
Céline Lamouroux: UMRESTTE, UMR T 9405, Université Lyon 1, Université Gustave Eiffel—IFSTTAR, Domaine Rockefeller, 8 Avenue Rockefeller, 69008 Lyon, France
Carole Pélissier: Hospital University Center of Saint-Etienne, Université Lyon 1, Université de St Etienne, IFSTTAR, UMRESTTE, UMR T 9405, 42005 Saint-Etienne, France
Barbara Charbotel: UMRESTTE, UMR T 9405, Université Lyon 1, Université Gustave Eiffel—IFSTTAR, Domaine Rockefeller, 8 Avenue Rockefeller, 69008 Lyon, France

IJERPH, 2021, vol. 18, issue 24, 1-19

Abstract: Isocyanate, whose disease-inducing mechanism is poorly understood, with poor prognosis, is widely used. Asthma is the most frequent manifestation of prolonged exposure. We assessed the evolution of the incidence of isocyanate-induced occupational asthma over time. PubMed and Cochrane databases were systematically searched for studies published since 1990 that assessed the relationship between occupational exposure to isocyanates and asthma. We identified 39 studies: five retrospective cohort studies, seven prospective cohort studies, three of which were inception cohorts), seven observational cross-sectional studies, five literature reviews, two case series, and 13 registry studies. The incidence of occupational asthma secondary to isocyanate exposure has decreased from more than 5% in the early 1990s to 0.9% in 2017 in the United States. Despite the wide use of optimal collective and individual protection measures, the risk of occupational asthma has stabilized. Occupational asthma risk can be assessed with good sensitivity using self-questionnaires and pulmonary function tests. Occupational avoidance should be implemented as soon as possible after the first symptoms appear because the prognosis becomes increasingly poor with the persistence of exposure. It is now necessary to study specifically cutaneous sensitization to isocyanates and to define what protective equipment is effective against this mode of exposure.

Keywords: occupational asthma; isocyanates; systematic review (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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