Severe COVID-19 Complicated by Cerebral Venous Thrombosis in a Newborn Successfully Treated with Remdesivir, Glucocorticoids, and Hyperimmune Plasma

Laura Cursi, Francesca Ippolita Calo Carducci, Sara Chiurchiu, Lorenza Romani, Francesca Stoppa, Giulia Lucignani, Cristina Russo, Daniela Longo, Carlo Federico Perno, Corrado Cecchetti, Mary Haywood Lombardi, Patrizia D’Argenio, Laura Lancella, Stefania Bernardi and Paolo Rossi
Additional contact information
Laura Cursi: Academic Department of Pediatrics, Bambino Gesù Children’s Hospital—IRCCS, 00165 Rome, Italy
Francesca Ippolita Calo Carducci: Academic Department of Pediatrics, Bambino Gesù Children’s Hospital—IRCCS, 00165 Rome, Italy
Sara Chiurchiu: Academic Department of Pediatrics, Bambino Gesù Children’s Hospital—IRCCS, 00165 Rome, Italy
Lorenza Romani: Academic Department of Pediatrics, Bambino Gesù Children’s Hospital—IRCCS, 00165 Rome, Italy
Francesca Stoppa: Department of Emergency, Acceptance and General Pediatrics, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Giulia Lucignani: Imaging Department, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Cristina Russo: Department of Laboratories, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Daniela Longo: Imaging Department, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Carlo Federico Perno: Department of Laboratories, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Corrado Cecchetti: Department of Emergency, Acceptance and General Pediatrics, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Mary Haywood Lombardi: Department of Emergency, Acceptance and General Pediatrics, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Patrizia D’Argenio: Academic Department of Pediatrics, Bambino Gesù Children’s Hospital—IRCCS, 00165 Rome, Italy
Laura Lancella: Academic Department of Pediatrics, Bambino Gesù Children’s Hospital—IRCCS, 00165 Rome, Italy
Stefania Bernardi: Academic Department of Pediatrics, Bambino Gesù Children’s Hospital—IRCCS, 00165 Rome, Italy
Paolo Rossi: Academic Department of Pediatrics, Bambino Gesù Children’s Hospital—IRCCS, 00165 Rome, Italy

IJERPH, 2021, vol. 18, issue 24, 1-9

Abstract: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) pandemic, affecting all age groups with a wide spectrum of clinical presentation ranging from asymptomatic to severe interstitial pneumonia, hyperinflammation, and death. Children and infants generally show a mild course of the disease, although infants have been observed to have a higher risk of hospitalization and severe outcomes. Here, we report the case of a preterm infant with a severe form of SARS-CoV-2 infection complicated by cerebral venous thrombosis successfully treated with steroids, hyperimmune plasma, and remdesivir.

Keywords: newborn; SARS-CoV-2; COVID-19; cerebral thrombosis; remdesivir (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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