Prevalence of Hyperuricemia and the Use of Allopurinol in Older Poles—Results from a Population-Based PolSenior Study

Mateusz Winder, Aleksander J. Owczarek, Małgorzata Mossakowska, Katarzyna Broczek, Tomasz Grodzicki, Łukasz Wierucki and Jerzy Chudek
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Mateusz Winder: Department of Internal Medicine and Oncological Chemotherapy, Medical University of Silesia, 40-029 Katowice, Poland
Aleksander J. Owczarek: Department of Statistics, Department of Instrumental Analysis, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 41-200 Katowice, Poland
Małgorzata Mossakowska: International Institute of Molecular and Cell Biology, 02-109 Warsaw, Poland
Katarzyna Broczek: Department of Geriatrics, Medical University of Warsaw, 02-007 Warsaw, Poland
Tomasz Grodzicki: Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, 31-531 Krakow, Poland
Łukasz Wierucki: Department of Preventive Medicine and Education, Medical University of Gdańsk, 80-210 Gdansk, Poland
Jerzy Chudek: Department of Internal Medicine and Oncological Chemotherapy, Medical University of Silesia, 40-029 Katowice, Poland

IJERPH, 2021, vol. 18, issue 2, 1-14

Abstract: Background: Our study analyzes the frequency and risk factors of hyperuricemia and the use of allopurinol in a representative cohort of the older Polish adult population. Methods: The analysis was a part of a cross-sectional PolSenior study on aging in Poland. The complete medication data were available in 4873 out of 4979 community dwelling respondents aged 65 and over. Serum uric acid concentrations were evaluated in 4028 participants (80.9% of the cohort). Results: Hyperuricemia was observed in 28.2% of women and 24.7% of men. Ten risk factors of hyperuricemia were selected based on multivariable LASSO logistic regression analysis. Nine factors showed significant odds ratios: eGFR < 60 mL/min/1.73 m 2 (OR = 4.10), hypertriglyceridemia (OR = 1.88), obesity (OR = 1.75), heart failure (1.70), CRP > 3.0 mg/dL (OR = 1.64), coronary artery disease (OR = 1.30), use of loop-diuretics (OR = 4.20), hydrochlorothiazide (OR = 2.96), and thiazide-like diuretics (OR = 2.81). Allopurinol was used by 2.8% of men and 1.8% of women. The therapy was considered effective in 46.7% of men and 53.3% of women. Conclusions: Hyperuricemia was present in 23.1% (95% CI: 21.8–24.4) of the older Polish population. The frequency of hyperuricemia increases with age, reaching 30.5% in men and 33.7% in women aged 90 years or more. Chronic kidney disease, obesity, heart failure, hypertriglyceridemia, and the use of diuretics were the strongest risk factors for hyperuricemia in older adults. The treatment with allopurinol was ineffective in more than half of participants.

Keywords: hyperuricemia; prevalence; elderly; allopurinol (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View complete reference list from CitEc
Citations: View citations in EconPapers (3)

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