Association of P10L Polymorphism in Melanopsin Gene with Chronic Insomnia in Mexicans

Bianca Ethel Gutiérrez-Amavizca, Ernesto Prado Montes de Oca, Jaime Paul Gutiérrez-Amavizca, Oscar David Castro, Cesar Heriberto Ruíz-Marquez, Kricel Perez Conde-Andreu, Ricardo Pérez Calderón, Marisela Aguirre Ramírez and Jorge Alberto Pérez-León
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Bianca Ethel Gutiérrez-Amavizca: Chemical Biological Sciences PhD Graduate Program, Department of Chemical Sciences, Biomedical Sciences Institute, Ciudad Juarez Autonomous University, Chihuahua 32310, Mexico
Ernesto Prado Montes de Oca: Laboratory of Regulatory SNPs and Laboratory of Pharmacogenomics and Preventive Medicine, Personalized Medicine National Laboratory (LAMPER), Pharmaceutical and Medical Biotechnology, Central Unit, CIATEJ, A.C., National Council of Science and Technology (CONACYT), Guadalajara 44270, Mexico
Jaime Paul Gutiérrez-Amavizca: Chemical Biological Sciences PhD Graduate Program, Department of Chemical Sciences, Biomedical Sciences Institute, Ciudad Juarez Autonomous University, Chihuahua 32310, Mexico
Oscar David Castro: Chemical Biological Sciences PhD Graduate Program, Department of Chemical Sciences, Biomedical Sciences Institute, Ciudad Juarez Autonomous University, Chihuahua 32310, Mexico
Cesar Heriberto Ruíz-Marquez: Chemical Biological Sciences PhD Graduate Program, Department of Chemical Sciences, Biomedical Sciences Institute, Ciudad Juarez Autonomous University, Chihuahua 32310, Mexico
Kricel Perez Conde-Andreu: Chemical Biological Sciences PhD Graduate Program, Department of Chemical Sciences, Biomedical Sciences Institute, Ciudad Juarez Autonomous University, Chihuahua 32310, Mexico
Ricardo Pérez Calderón: Genomics Sciences Masters Program, Department of Chemical Sciences, Biomedical Sciences Institute, Ciudad Juarez Autonomous University, Chihuahua 32310, Mexico
Marisela Aguirre Ramírez: Chemical Biological Sciences PhD Graduate Program, Department of Chemical Sciences, Biomedical Sciences Institute, Ciudad Juarez Autonomous University, Chihuahua 32310, Mexico
Jorge Alberto Pérez-León: Chemical Biological Sciences PhD Graduate Program, Department of Chemical Sciences, Biomedical Sciences Institute, Ciudad Juarez Autonomous University, Chihuahua 32310, Mexico

IJERPH, 2021, vol. 18, issue 2, 1-10

Abstract: The aim of this pilot study was to determine the association of the P10L (rs2675703) polymorphism of the OPN4 gene with chronic insomnia in uncertain etiology in a Mexican population. A case control study was performed including 98 healthy subjects and 29 individuals with chronic insomnia not related to mental disorders, medical condition, medication or substance abuse. Samples were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Genetic analyses showed that the T allele of P10L increased risk to chronic insomnia in a dominant model ( p = 1 ×10 −4 ; odds ratio (OR) = 9.37, CI = 8.18–335.66, Kelsey statistical power (KSP) = 99.9%), and in a recessive model ( p = 7.5 × 10 −5 , OR = 9.37, KSP = 99.3%, CI = 2.7–34.29). In the insomnia group, we did not find a correlation between genotypes and chronotype ( p = 0.219 Fisher’s exact test), severity of chronic insomnia using ISI score ( p = 0.082 Fisher’s exact test) and ESS score ( p ? 0.999 Fisher’s exact test). However, evening chronotype was correlated to daytime sleepiness severity, individuals with an eveningness chronotype had more severe drowsiness according to their insomnia severity index (ISI) score ( p = 0.021 Fisher’s exact test) and Epworth sleepiness scale (ESS) score ( p = 0.015 Fisher’s exact test) than the morningness and intermediate chronotype. We demonstrated that the T allele of the P10L polymorphism in the OPN4 gene is associated with chronic insomnia in Mexicans. We suggest the need to conduct larger studies in different ethnic populations to test the probable association and function of P10L and other SNPs in the OPN4 gene and in the onset of chronic insomnia.

Keywords: OPN4 gene; melanopsin; insomnia; SNPs; retina; chronotypes (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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