Neurodevelopmental Outcomes at 18 Months of Corrected Age for Late Preterm Infants Born at 34 and 35 Gestational Weeks

Ruka Nakasone, Kazumichi Fujioka, Yuki Kyono, Asumi Yoshida, Takumi Kido, Shutaro Suga, Shinya Abe, Mariko Ashina, Kosuke Nishida, Kenji Tanimura, Hideto Yamada, Kandai Nozu and Kazumoto Iijima
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Ruka Nakasone: Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
Kazumichi Fujioka: Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
Yuki Kyono: Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
Asumi Yoshida: Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
Takumi Kido: Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
Shutaro Suga: Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
Shinya Abe: Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
Mariko Ashina: Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
Kosuke Nishida: Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
Kenji Tanimura: Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
Hideto Yamada: Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
Kandai Nozu: Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
Kazumoto Iijima: Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 6500017, Japan

IJERPH, 2021, vol. 18, issue 2, 1-11

Abstract: To date, the difference in neurodevelopmental outcomes between late preterm infants (LPI) born at 34 and 35 gestational weeks (LPI-34 and LPI-35, respectively) has not been elucidated. This retrospective study aimed to evaluate neurodevelopmental outcomes at 18 months of corrected age for LPI-34 and LPI-35, and to elucidate factors predicting neurodevelopmental impairment (NDI). Records of all LPI-34 ( n = 93) and LPI-35 ( n = 121) admitted to our facility from 2013 to 2017 were reviewed. Patients with congenital or chromosomal anomalies, severe neonatal asphyxia, and without developmental quotient (DQ) data were excluded. Psychomotor development was assessed as a DQ using the Kyoto Scale of Psychological Development at 18 months of corrected age. NDI was defined as DQ < 80 or when severe neurodevelopmental problems made neurodevelopmental assessment impossible. We compared the clinical characteristics and DQ values between LPI-34 (n = 62) and LPI-35 ( n = 73). To elucidate the factors predicting NDI at 18 months of corrected age, we compared clinical factors between the NDI ( n = 17) and non-NDI ( n = 118) groups. No significant difference was observed in DQ values at 18 months of corrected age between the groups in each area and overall. Among clinical factors, male sex, intraventricular hemorrhage (IVH), hyperbilirubinemia, and severe hyperbilirubinemia had a higher prevalence in the NDI group than in the non-NDI group, and IVH and/or severe hyperbilirubinemia showed the highest Youden Index values for predicting NDI. Based on the results of this study, we can conclude that no significant difference in neurodevelopmental outcomes at 18 months of corrected age was observed between LPI-34 and LPI-35. Patients with severe hyperbilirubinemia and/or IVH should be considered to be at high risk for developing NDI.

Keywords: late preterm infants; neurodevelopmental outcome; neurodevelopmental impairment (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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