Subjective Psychophysical Experiences in the Course of Inflammatory Bowel Disease—A Comparative Analysis Based on the Polish Pediatric Crohn’s and Colitis Cohort (POCOCO)

Aleksandra Glapa-Nowak, Anna Bukowska-Posadzy, Mariusz Szczepanik, Jarosław Kwiecień, Anna Szaflarska-Popławska, Barbara Iwańczak, Anna Flak-Wancerz, Łukasz Dembiński, Marcin Osiecki, Jarosław Kierkuś, Tomasz Banasiewicz, Harald Walach, Aleksandra Banaszkiewicz and Jarosław Walkowiak
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Aleksandra Glapa-Nowak: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznań University of Medical Sciences, 60-572 Poznan, Poland
Anna Bukowska-Posadzy: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznań University of Medical Sciences, 60-572 Poznan, Poland
Mariusz Szczepanik: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznań University of Medical Sciences, 60-572 Poznan, Poland
Jarosław Kwiecień: Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland
Anna Szaflarska-Popławska: Department of Pediatric Endoscopy and Gastrointestinal Function Testing, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 85-067 Bydgoszcz, Poland
Barbara Iwańczak: Department and Clinic of Pediatrics, Gastroenterology and Nutrition, Wroclaw Medical University, 50-369 Wroclaw, Poland
Anna Flak-Wancerz: Department of Pediatrics, Faculty of Medical Sciences, Medical University of Silesia in Katowice, 40-752 Katowice, Poland
Łukasz Dembiński: Department of Pediatric Gastroenterology and Nutrition, Medical University of Warsaw, 02-097 Warsaw, Poland
Marcin Osiecki: The Department of Gastroenterology, Hepatology, Feeding Disorders and Paediatrics, The Children’s Memorial Health Institute, 04-730 Warsaw, Poland
Jarosław Kierkuś: The Department of Gastroenterology, Hepatology, Feeding Disorders and Paediatrics, The Children’s Memorial Health Institute, 04-730 Warsaw, Poland
Tomasz Banasiewicz: Chair and Department of General Surgery, Gastroenterological Surgical Oncology and Plastic Surgery, Poznań University of Medical Sciences, 60-355 Poznan, Poland
Harald Walach: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznań University of Medical Sciences, 60-572 Poznan, Poland
Aleksandra Banaszkiewicz: Department of Pediatric Gastroenterology and Nutrition, Medical University of Warsaw, 02-097 Warsaw, Poland
Jarosław Walkowiak: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznań University of Medical Sciences, 60-572 Poznan, Poland

IJERPH, 2021, vol. 18, issue 2, 1-11

Abstract: No gold standard is available to evaluate subjective psychophysical experiences in pediatric inflammatory bowel disease (IBD). We aimed to assess pain, anxiety, and limitations in social activities at diagnosis and the worst flare of the disease in relation to clinical expression, treatment and IBD severity. A total of 376 children completed the survey (Crohn’s disease (CD) n = 196; ulcerative colitis (UC) n = 180). The questionnaire included 12 questions regarding pain, anxiety, and social activity, all assessed at recruitment and retrospectively at diagnosis and worst flare using a numeric rating scale. Patients that had ever been treated with systemic glucocorticosteroids scored higher in pain ( p < 0.001), anxiety ( p = 0.015), and social activity domains ( p < 0.016) at worst flare, and the answers correlated with the number of steroid courses ( p < 0.0392). The perception of social activity limitations also correlated independently with the number of immunosuppressants ( p < 0.0433) and biological agents ( p < 0.0494). There was no difference in retrospective perception of pain, anxiety and social activity limitations between CD and UC patients at diagnosis and the worst flare. The level of limitations in social activity correlated with hospitalisations due to relapse, days spent in the hospital, number of relapses, and severe relapses with the strongest association of rho = 0.39 ( p = 0.0004). Subjective and retrospective perception of pain, anxiety, and limitations in social activity differs depending on therapy, correlates with treatment modalities, and severity measures such as hospitalisations.

Keywords: Crohn’s disease; ulcerative colitis; pain; anxiety; social activity (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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