Effects of Untreated Drinking Water at Three Indigenous Yaqui Towns in Mexico: Insights from a Murine Model

Sofia Navarro-Espinoza, Aracely Angulo-Molina, Diana Meza-Figueroa, Guillermo López-Cervantes, Mercedes Meza-Montenegro, Aurora Armienta, Diego Soto-Puebla, Erika Silva-Campa, Alexel Burgara-Estrella, Osiris Álvarez-Bajo and Martín Pedroza-Montero
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Sofia Navarro-Espinoza: Department of Geology, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico
Aracely Angulo-Molina: Department of Physics Research, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico
Diana Meza-Figueroa: Department of Geology, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico
Guillermo López-Cervantes: Department of Medicine, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico
Mercedes Meza-Montenegro: Department of Natural Resources, Sonora Technological Institute, 5 de Febrero 818 Sur, Obregon City 85000, Sonora, Mexico
Aurora Armienta: Institute of Geophysics, National Autonomous University of Mexico-UNAM, Coyoacán 04510, Ciudad de Mexico, Mexico
Diego Soto-Puebla: Department of Biological Chemical Sciences, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico
Erika Silva-Campa: Department of Biological Chemical Sciences, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico
Alexel Burgara-Estrella: Department of Biological Chemical Sciences, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico
Osiris Álvarez-Bajo: Department of Biological Chemical Sciences, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico
Martín Pedroza-Montero: Department of Biological Chemical Sciences, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico

IJERPH, 2021, vol. 18, issue 2, 1-14

Abstract: Background: Reports in a northwestern Mexico state linked arsenic (As) in drinking water to DNA damage in people from indigenous communities. However, this correlation remains under discussion due to unknown variables related to nutrition, customs, and the potential presence of other metal(oid)s. Methods: To determine this association, we sampled water from three Yaqui towns (Cócorit, Vícam, and Pótam), and analyzed the metals by ICP-OES. We exposed four separate groups, with five male CD-1 mice each, to provide further insight into the potential effects of untreated drinking water. Results: The maximum concentrations of each metal(oid) in µg·L −1 were Sr(819) > Zn(135) > As(75) > Ba(57) > Mo(56) > Cu(17) > Al(14) > Mn(12) > Se(19). Histological studies revealed brain cells with angulation, satellitosis, and reactive gliosis with significant statistical correlation with Mn and As. Furthermore, the liver cells presented hepatocellular degeneration. Despite the early response, there is no occurrence of both statistical and significative changes in hematological parameters. Conclusions: The obtained results provide experimental insights to understand the potential effects of untreated water with low As and Mn contents in murine models. This fact is noteworthy because of the development of histological changes on both the brain and liver at subchronic exposure.

Keywords: indigenous towns; drinking water; murine model; arsenic; manganese (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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