An Association between Lower Extremity Function and Cognitive Frailty: A Sample Population from the KFACS Study

Gwon-Min Kim, Bo-Kun Kim, Du-Ri Kim, Yung Liao, Jong-Hwan Park and Hyuntae Park
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Gwon-Min Kim: Health Convergence Medicine Laboratory, Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Korea
Bo-Kun Kim: Faculty of Sports Health Care, In-je University, Gimhae 50834, Korea
Du-Ri Kim: Health Convergence Medicine Laboratory, Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Korea
Yung Liao: Department of Health Promotion and Health Education, National Taiwan Normal University, Taipei 106, Taiwan
Jong-Hwan Park: Health Convergence Medicine Laboratory, Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Korea
Hyuntae Park: Department of Health Sciences, Graduate School, Dong-A University, Busan 49315, Korea

IJERPH, 2021, vol. 18, issue 3, 1-9

Abstract: The present study aimed to define the physical function and lipid profile for physical and cognitive frailty in community-dwelling Korean older adults. A total of 229 participants (age = 76.76 ± 3.72 years; body mass index = 24.83 ± 3.15) were classified into four groups: robust, pre-frailty, cognitive decline, and cognitive frailty. An analysis on the four groups was performed to measure their physical and cognitive function, as well as blood biomarkers. The area under (AUC) the receiver operating characteristic curve (ROC) indicated that the 6-min Walk Test (6MWT), Timed Up and Go test (TUG), and Five Times Sit-to-Stand test (FTSS) had the potential to distinguish the capacity of an old adult to predict cognitive frailty. The 6MWT had a higher sensitivity and the TUG and FTSS tests had greater specificity. With cognitive frailty as a categorical variable, cognitive frailty status was a significant predictor of the TUG (odds ratio (OR) 2.897; 95% confidence interval (CI), 1.283–6.541), FTSS (OR 3.337; 95% CI 1.451–7.673), and 6MWT (OR 0.204; 95% CI 0.070–0.591) tests. Our findings indicate that the 6MWT, TUG, and FTSS tests are closely related to cognitive frailty and can provide potential prognostic cutoff points.

Keywords: cognitive frailty; Timed Up and Go test; Five Times Sit-to-Stand test; 6-min Walk Test; lower extremity function (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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