Short-Term Effects of Air Pollution on Cardiovascular Hospitalizations in the Pisan Longitudinal Study

Salvatore Fasola, Sara Maio, Sandra Baldacci, Stefania La Grutta, Giuliana Ferrante, Francesco Forastiere, Massimo Stafoggia, Claudio Gariazzo, Camillo Silibello, Giuseppe Carlino, Giovanni Viegi and on behalf of the BEEP Collaborative Group
Additional contact information
Salvatore Fasola: Institute for Biomedical Research and Innovation, National Research Council, 90146 Palermo, Italy
Sara Maio: Institute of Clinical Physiology, National Research Council, 56126 Pisa, Italy
Sandra Baldacci: Institute of Clinical Physiology, National Research Council, 56126 Pisa, Italy
Stefania La Grutta: Institute for Biomedical Research and Innovation, National Research Council, 90146 Palermo, Italy
Giuliana Ferrante: Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90127 Palermo, Italy
Francesco Forastiere: Institute for Biomedical Research and Innovation, National Research Council, 90146 Palermo, Italy
Massimo Stafoggia: Department of Epidemiology, Lazio Region Health Service—ASL Roma 1, 00147 Rome, Italy
Claudio Gariazzo: Occupational and Environmental Medicine, Epidemiology and Hygiene Department, Italian Workers’ Compensation Authority (INAIL), Monte Porzio Catone, 00144 Rome, Italy
Camillo Silibello: Arianet S.r.l., 20128 Milan, Italy
Giuseppe Carlino: Simularia S.r.l., 10121 Turin, Italy
Giovanni Viegi: Institute for Biomedical Research and Innovation, National Research Council, 90146 Palermo, Italy
on behalf of the BEEP Collaborative Group: Membership of the BEEP Collaborative Group is provided in the Acknowledgments.

IJERPH, 2021, vol. 18, issue 3, 1-17

Abstract: Air pollution effects on cardiovascular hospitalizations in small urban/suburban areas have been scantly investigated. Such effects were assessed among the participants in the analytical epidemiological survey carried out in Pisa and Cascina, Tuscany, Italy (2009–2011). Cardiovascular hospitalizations from 1585 subjects were followed up (2011–2015). Daily mean pollutant concentrations were estimated through random forests at 1 km (particulate matter: PM 10 , 2011–2015; PM 2.5 , 2013–2015) and 200 m (PM 10 , PM 2.5 , NO 2 , O 3 , 2013–2015) resolutions. Exposure effects were estimated using the case-crossover design and conditional logistic regression (odds ratio—OR—and 95% confidence interval—CI—for 10 ?g/m 3 increase; lag 0–6). During the period 2011–2015 (137 hospitalizations), a significant effect at lag 0 was observed for PM 10 (OR = 1.137, CI: 1.023–1.264) at 1 km resolution. During the period 2013–2015 (69 hospitalizations), significant effects at lag 0 were observed for PM 10 (OR = 1.268, CI: 1.085–1.483) and PM 2.5 (OR = 1.273, CI: 1.053–1.540) at 1 km resolution, as well as for PM 10 (OR = 1.365, CI: 1.103–1.690), PM 2.5 (OR = 1.264, CI: 1.006–1.589) and NO 2 (OR = 1.477, CI: 1.058–2.061) at 200 m resolution; significant effects were observed up to lag 2. Larger ORs were observed in males and in subjects reporting pre-existent cardiovascular/respiratory diseases. Combining analytical and routine epidemiological data with high-resolution pollutant estimates provides new insights on acute cardiovascular effects in the general population and in potentially susceptible subgroups living in small urban/suburban areas.

Keywords: air pollution; cardiovascular hospitalizations; case-crossover design; epidemiology; high-resolution pollutant estimates; small cities; suburban areas (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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