Sirt1 Activity in the Brain: Simultaneous Effects on Energy Homeostasis and Reproduction

Stefania D’Angelo, Elena Mele, Federico Di Filippo, Andrea Viggiano and Rosaria Meccariello
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Stefania D’Angelo: Department of Movement Sciences and Wellbeing, University of Naples Parthenope, 80133 Napoli, Italy
Elena Mele: Department of Movement Sciences and Wellbeing, University of Naples Parthenope, 80133 Napoli, Italy
Federico Di Filippo: Deptartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, via Allende, 84081 Baronissi (SA), Italy
Andrea Viggiano: Deptartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, via Allende, 84081 Baronissi (SA), Italy
Rosaria Meccariello: Department of Movement Sciences and Wellbeing, University of Naples Parthenope, 80133 Napoli, Italy

IJERPH, 2021, vol. 18, issue 3, 1-17

Abstract: Diet deeply impacts brain functions like synaptic plasticity and cognitive processes, neuroendocrine functions, reproduction and behaviour, with detrimental or protective effects on neuronal physiology and therefore consequences for health. In this respect, the activity of metabolic sensors within the brain is critical for the maintenance of health status and represents a possible therapeutic target for some diseases. This review summarizes the main activity of Sirtuin1 (Sirt1), a metabolic sensor within the brain with a focus on the link between the central control of energy homeostasis and reproduction. The possible modulation of Sirt1 by natural phytochemical compounds like polyphenols is also discussed.

Keywords: Sirt1; brain; energy homeostasis; reproduction; kisspeptin; polyphenols (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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