Additive Manufacturing of Resected Oral and Oropharyngeal Tissue: A Pilot Study

Alexandria L. Irace, Anne Koivuholma, Eero Huotilainen, Jaana Hagström, Katri Aro, Mika Salmi, Antti Markkola, Heli Sistonen, Timo Atula and Antti A. Mäkitie
Additional contact information
Alexandria L. Irace: Department of Otorhinolaryngology–Head and Neck Surgery, HUS Helsinki University Hospital, University of Helsinki, P.O.Box 263, FI-00029 HUS Helsinki, Finland
Anne Koivuholma: Department of Otorhinolaryngology–Head and Neck Surgery, HUS Helsinki University Hospital, University of Helsinki, P.O.Box 263, FI-00029 HUS Helsinki, Finland
Eero Huotilainen: Department of Mechanical Engineering, Aalto University, P.O.Box 14100, FI-00076 Aalto Espoo, Finland
Jaana Hagström: Department of Pathology, HUS Helsinki University Hospital, University of Helsinki, P.O. Box 21, Haartmaninkatu 3, FI-00029 HUS Helsinki, Finland
Katri Aro: Department of Otorhinolaryngology–Head and Neck Surgery, HUS Helsinki University Hospital, University of Helsinki, P.O.Box 263, FI-00029 HUS Helsinki, Finland
Mika Salmi: Department of Mechanical Engineering, Aalto University, P.O.Box 14100, FI-00076 Aalto Espoo, Finland
Antti Markkola: Department of Imaging, HUS Helsinki University Hospital, University of Helsinki, FI-00029 HUS Helsinki, Finland
Heli Sistonen: Department of Imaging, HUS Helsinki University Hospital, University of Helsinki, FI-00029 HUS Helsinki, Finland
Timo Atula: Department of Otorhinolaryngology–Head and Neck Surgery, HUS Helsinki University Hospital, University of Helsinki, P.O.Box 263, FI-00029 HUS Helsinki, Finland
Antti A. Mäkitie: Department of Otorhinolaryngology–Head and Neck Surgery, HUS Helsinki University Hospital, University of Helsinki, P.O.Box 263, FI-00029 HUS Helsinki, Finland

IJERPH, 2021, vol. 18, issue 3, 1-12

Abstract: Better visualization of tumor structure and orientation are needed in the postoperative setting. We aimed to assess the feasibility of a system in which oral and oropharyngeal tumors are resected, photographed, 3D modeled, and printed using additive manufacturing techniques. Three patients diagnosed with oral/oropharyngeal cancer were included. All patients underwent preoperative magnetic resonance imaging followed by resection. In the operating room (OR), the resected tissue block was photographed using a smartphone. Digital photos were imported into Agisoft Photoscan to produce a digital 3D model of the resected tissue. Physical models were then printed using binder jetting techniques. The aforementioned process was applied in pilot cases including carcinomas of the tongue and larynx. The number of photographs taken for each case ranged from 63 to 195. The printing time for the physical models ranged from 2 to 9 h, costs ranging from 25 to 141 EUR (28 to 161 USD). Digital photography may be used to additively manufacture models of resected oral/oropharyngeal tumors in an easy, accessible and efficient fashion. The model may be used in interdisciplinary discussion regarding postoperative care to improve understanding and collaboration, but further investigation in prospective studies is required.

Keywords: additive manufacturing; rapid manufacturing; stereolithography; 3D imaging; head and neck surgery; surgical oncology (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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