Association between Vitamin D Receptor Polymorphisms (BsmI and FokI) and Glycemic Control among Patients with Type 2 Diabetes

Wan Nur Amalina Zakaria, Nazihah Mohd Yunus, Najib Majdi Yaacob, Julia Omar, Wan Mohd Izani Wan Mohamed, K. N. S. Sirajudeen and Tuan Salwani Tuan Ismail
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Wan Nur Amalina Zakaria: Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kota Bharu 16150, Malaysia
Nazihah Mohd Yunus: Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kota Bharu 16150, Malaysia
Najib Majdi Yaacob: Unit of Biostatistics and Research Methodology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kota Bharu 16150, Malaysia
Julia Omar: Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kota Bharu 16150, Malaysia
Wan Mohd Izani Wan Mohamed: Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kota Bharu 16150, Malaysia
K. N. S. Sirajudeen: Department of Basic Medical Sciences, Kuliyyah of Medicine, International Islamic University Malaysia, Bandar Indera Mahkota, Kuantan 25200, Malaysia
Tuan Salwani Tuan Ismail: Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kota Bharu 16150, Malaysia

IJERPH, 2021, vol. 18, issue 4, 1-18

Abstract: (1) Background: Several studies have suggested that the vitamin D receptor (VDR) gene plays a role in type 2 diabetes mellitus (T2DM) susceptibility. Nonetheless, the association between T2DM and VDR polymorphisms remains inconclusive. We determined the genotype of VDR rs1544410 (BsmI) and rs2228570 (FokI) polymorphisms among Malaysian patients with T2DM and their association with glycemic control factors (vitamin D levels, calcium, magnesium, and phosphate). (2) Methods: A total of 189 participants comprising 126 patients with T2DM (63 with good glycemic control and 63 with poor glycemic control) and 63 healthy controls were enrolled in this case–control study. All biochemical assays were measured using spectrophotometric analysis. VDR gene FokI and BsmI polymorphisms were analyzed using polymerase chain reaction and endonuclease digestion. (3) Results: Our findings revealed no significant differences in VDR FokI and BsmI genotypes between participants with T2DM and healthy controls. Moreover, no significant association was observed between both single nucleotide polymorphisms and glycemic control factors. Participants with poor glycemic control had significantly lower serum magnesium levels and significantly higher HOMA-IR compared to the other groups. (4) Conclusions: The present study revealed that VDR gene BsmI and FokI polymorphisms were not significantly associated with T2DM.

Keywords: vitamin D receptor; type 2 diabetes mellitus; BsmI; FokI; glycemic control (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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