Association Between PM 2.5 Exposure Level and Primary Open-Angle Glaucoma in Taiwanese Adults: A Nested Case–control Study

Han-Yin Sun, Ci-Wen Luo, Yun-Wei Chiang, Kun-Lin Yeh Yi-Ching Li, Yung-Chung Ho, Shiuan-Shinn Lee, Wen-Ying Chen, Chun-Jung Chen and Yu-Hsiang Kuan
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Han-Yin Sun: Department of Optometry, Chung Shan Medical University, Taichung 40201, Taiwan
Ci-Wen Luo: Department of Pharmacology, School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
Yun-Wei Chiang: Department of life sciences, National Chung-Hsing University, Taichung 402204, Taiwan
Kun-Lin Yeh Yi-Ching Li: Department of Pharmacology, School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
Yung-Chung Ho: School of Medical Applied Chemistry, Chung Shan Medical University, Taichung 40201, Taiwan
Shiuan-Shinn Lee: School of Public Health, Chung Shan Medical University, Taichung 40201, Taiwan
Wen-Ying Chen: Department of Veterinary Medicine, National Chung Hsing University, Taichung 402204, Taiwan
Chun-Jung Chen: Department of Education and Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan
Yu-Hsiang Kuan: Department of Pharmacology, School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan

IJERPH, 2021, vol. 18, issue 4, 1-12

Abstract: Primary open-angle glaucoma (POAG) is the most common type of glaucoma. However, little is known about POAG in adults and exposure to air pollution. The current study aims to investigate whether exposure to particulate matter with a mass median aerodynamic diameter of ?2.5 ?m (PM 2.5 ) is associated with POAG diagnosis. Patient data were obtained from the Longitudinal Health Insurance Database 2010 (LHID2010) of Taiwan for the 2008–2013 period. PM 2.5 concentration data, collected from the Ambient Air Quality Monitoring Network established by the Environmental Protection Administration of Taiwan, were categorized into four groups according to World Health Organization (WHO) exposure standards for PM 2.5 . We estimated the odds ratios (ORs) and 95% CIs for risk factors for POAG with logistic regression. The OR of per WHO standard level increase was 1.193 (95% CI 1.050–1.356). Compared with the normal level, the OR of WHO 2.0 level was 1.668 (95% CI 1.045–2.663, P < 0.05). After excluding confounding risk factors for POAG in this study, we determined that increased PM 2.5 exposure is related to POAG risk (ORs > 1, P < 0.05). In this study, PM 2.5 was an independent factor associated with open-angle glaucoma. Further research is required to better understand the mechanisms connecting PM 2.5 and open-angle glaucoma.

Keywords: PM 2.5; primary open-angle glaucoma; Taiwanese adults; nested case–control study (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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