Urinary Bisphenol A, F and S Levels and Semen Quality in Young Adult Danish Men

Thea Emily Benson, Anne Gaml-Sørensen, Andreas Ernst, Nis Brix, Karin Sørig Hougaard, Katia Keglberg Hærvig, Jens Peter Ellekilde Bonde, Sandra Søgaard Tøttenborg, Christian H. Lindh, Cecilia Høst Ramlau-Hansen and Gunnar Toft
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Thea Emily Benson: Department of Public Health, Research Unit for Epidemiology, Aarhus University, 8000 Aarhus, Denmark
Anne Gaml-Sørensen: Department of Public Health, Research Unit for Epidemiology, Aarhus University, 8000 Aarhus, Denmark
Andreas Ernst: Department of Public Health, Research Unit for Epidemiology, Aarhus University, 8000 Aarhus, Denmark
Nis Brix: Department of Public Health, Research Unit for Epidemiology, Aarhus University, 8000 Aarhus, Denmark
Karin Sørig Hougaard: Department of Public Health, The Faculty of Health Sciences, University of Copenhagen, 1014 Copenhagen, Denmark
Katia Keglberg Hærvig: Department of Public Health, The Faculty of Health Sciences, University of Copenhagen, 1014 Copenhagen, Denmark
Jens Peter Ellekilde Bonde: Department of Public Health, The Faculty of Health Sciences, University of Copenhagen, 1014 Copenhagen, Denmark
Sandra Søgaard Tøttenborg: Department of Occupational and Environmental Medicine, Bispebjerg and Frederiksberg Hospital, 2400 Copenhagen, Denmark
Christian H. Lindh: Division of Occupational and Environmental Medicine, Lund University, 22363 Lund, Sweden
Cecilia Høst Ramlau-Hansen: Department of Public Health, Research Unit for Epidemiology, Aarhus University, 8000 Aarhus, Denmark
Gunnar Toft: Department of Clinical Medicine, Department of Clinical Epidemiology, Aarhus University, 8200 Aarhus, Denmark

IJERPH, 2021, vol. 18, issue 4, 1-12

Abstract: Bisphenol A (BPA) is considered an endocrine disruptor and has been associated with deleterious effects on spermatogenesis and male fertility. Bisphenol F (BPF) and S (BPS) are structurally similar to BPA, but knowledge of their effects on male fertility remains limited. In this cross–sectional study, we investigated the associations between exposure to BPA, BPF, and BPS and semen quality in 556 men 18–20 years of age from the Fetal Programming of Semen Quality (FEPOS) cohort. A urine sample was collected from each participant for determination of BPA, BPF, and BPS concentrations while a semen sample was collected to determine ejaculate volume, sperm concentration, total sperm count, sperm motility, and sperm morphology. Associations between urinary bisphenol levels (continuous and quartile–divided) and semen characteristics were estimated using a negative binomial regression model adjusting for urine creatinine concentration, alcohol intake, smoking status, body mass index (BMI), fever, sexual abstinence time, maternal pre–pregnancy BMI, and first trimester smoking, and highest parental education during first trimester. We found no associations between urinary bisphenol of semen quality in a sample of young men from the general Danish population.

Keywords: bisphenol; endocrine disruptor; epidemiology; male fertility; semen quality (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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