Health-Related Quality of Life in Weight Loss Interventions: Results from the OPTIWIN Trial

Livia Dainelli, Dan Roberto Luo, Sarah S. Cohen, Agnieszka Marczewska, Jamy D. Ard, Sally L. Coburn, Kristina H. Lewis, Judy Loper, Laura E. Matarese, Walter J. Pories and Amy E. Rothberg
Additional contact information
Livia Dainelli: Nestlé Research, Nestlé, 1000 Lausanne, Switzerland
Dan Roberto Luo: Nestlé Research, Nestlé, 1000 Lausanne, Switzerland
Sarah S. Cohen: EpidStrategies, Durham, NC 27101, USA
Agnieszka Marczewska: Nestlé Health Science, Nestlé, 1015 Lausanne, Switzerland
Jamy D. Ard: Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA
Sally L. Coburn: Alaska Premier Health, Anchorage, AK 99503, USA
Kristina H. Lewis: Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA
Judy Loper: The Central Ohio Nutrition Center, Inc., Gohanna, OH 43230, USA
Laura E. Matarese: Department of Surgery, Brody School of Medicine, East Carolina University, Greenville, NC 27101, USA
Walter J. Pories: Department of Surgery, Brody School of Medicine, East Carolina University, Greenville, NC 27101, USA
Amy E. Rothberg: Department of Nutritional Sciences, School of Public Health and Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Harbour, MI 48109-2029, USA

IJERPH, 2021, vol. 18, issue 4, 1-11

Abstract: Obesity is highly prevalent and associated with several adverse outcomes including health-related quality-of-life (HRQoL), work productivity, and activity impairment. The objective of this study is to examine group differences in HRQoL and labor-related health outcomes among participants in the OPTIWIN program, which compared the effectiveness of two intensive behavioral weight loss interventions. Participants ( n = 273) were randomized to OPTIFAST ® (OP) or food-based (FB) dietary interventions for 52 weeks. HRQoL and labor-related health outcomes were measured at baseline, week 26, and week 52, using two questionnaires. At baseline, there were no differences between groups on the Impact of Weight on Quality-of-Life Questionnaire (IWQOL-Lite). At week 26, the OP group had statistically significant differences towards better HRQoL for Physical Function, Self-Esteem, and the total score compared with the FB group. At week 52, the OP group showed better HRQoL in the total score ( p = 0.0012) and in all but one domain. Moreover, the adjusted change-from-baseline normalized total score at week 52 was ?5.9 points ( p = 0.0001). Finally, the mean IWQOL-Lite normalized score showed that HRQoL improves by 0.4442 units ( p < 0.0001) per kg lost, and that greater weight reduction was positively associated with better HRQoL. No statistically significant group differences were found with the Work Productivity and Activity Impairment (General Health) (WPAI-GH) Questionnaire. HRQoL improves with highly intensive, well-structured weight loss interventions. Greater weight loss lead to larger improvements. The lack of negative effect on productivity and activity suggests that these interventions may be compatible with an active work lifestyle.

Keywords: obesity; health-related quality-of-life; weight loss interventions; IWQOL-Lite; WPAI-GH (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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