Plasma Xanthine Oxidoreductase Activity Is Associated with a High Risk of Cardiovascular Disease in a General Japanese Population

Yuka Kotozaki, Mamoru Satoh, Kozo Tanno, Hideki Ohmomo, Ryo Otomo, Fumitaka Tanaka, Takahito Nasu, Satoru Taguchi, Hiroto Kikuchi, Takamasa Kobayashi, Atsushi Shimizu, Kiyomi Sakata, Jiro Hitomi, Kenji Sobue and Makoto Sasaki
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Yuka Kotozaki: Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Yahaba 028-3694, Japan
Mamoru Satoh: Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Yahaba 028-3694, Japan
Kozo Tanno: Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Yahaba 028-3694, Japan
Hideki Ohmomo: Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Yahaba 028-3694, Japan
Ryo Otomo: Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Yahaba 028-3694, Japan
Fumitaka Tanaka: Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Yahaba 028-3694, Japan
Takahito Nasu: Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Yahaba 028-3694, Japan
Satoru Taguchi: Division of Cardiology, Department of Internal Medicine, Iwate Medical University, Yahaba 028-3694, Japan
Hiroto Kikuchi: Division of Cardiology, Department of Internal Medicine, Iwate Medical University, Yahaba 028-3694, Japan
Takamasa Kobayashi: Division of Cardiology, Department of Internal Medicine, Iwate Medical University, Yahaba 028-3694, Japan
Atsushi Shimizu: Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Yahaba 028-3694, Japan
Kiyomi Sakata: Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Yahaba 028-3694, Japan
Jiro Hitomi: Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Yahaba 028-3694, Japan
Kenji Sobue: Department of Neuroscience, Institute for Biomedical Sciences, Iwate Medical University, Yahaba 028-3694, Japan
Makoto Sasaki: Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Yahaba 028-3694, Japan

IJERPH, 2021, vol. 18, issue 4, 1-10

Abstract: The purpose of this study was to investigate the association between xanthine oxidoreductase (XOR) activity and a high risk of cardiovascular disease (CVD) in a general Japanese population. The Iwate Tohoku Medical Megabank Organization pooled individual participant data from a general population-based cohort study in Iwate prefecture. The cardiovascular risk was calculated using the Framingham Risk Score (FRS). A total of 1605 of the 1631 participants (98.4%) had detectable XOR activity. Multiple regression analysis demonstrated that XOR activity was independently associated with body mass index (? = 0.26, p < 0.001), diabetes (? = 0.09, p < 0.001), dyslipidemia (? = 0.08, p = 0.001), and uric acid (? = 0.13, p < 0.001). Multivariate analysis showed that the highest quartile of XOR activity was associated with a high risk for CVD (FRS ? 15) after adjustment for baseline characteristics (OR 2.93, 95% CI 1.16–7.40). The area under the receiver operating characteristic curves of the FRS with XOR activity was 0.81 ( p = 0.008). XOR activity is associated with a high risk for CVD, suggesting that high XOR activity may indicate cardiovascular risk in a general Japanese population.

Keywords: atherosclerosis; Framingham Risk Score; the Iwate Tohoku Medical Megabank Organization; reactive oxygen species; uric acid (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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