Incidence Hypertension and Fasting Blood Glucose from Real-World Data: Retrospective Cohort for 7-Years Follow-Up

Soon-Ki Ahn, Ju-Mi Lee, Seon Mi Ji, Kyoung Hoon Kim, Jong-Heon Park and Min Kyung Hyun
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Soon-Ki Ahn: Public Health and Medical Services Office, Chungnam National University Hospital, Jung-gu, Daejeon 35015, Korea
Ju-Mi Lee: Department of Preventive Medicine, Eulji College of Medicine, Daejeon 34824, Korea
Seon Mi Ji: National Health Insurance Service, Wonju 26464, Korea
Kyoung Hoon Kim: Health Insurance Review & Assessment Service, Wonju 26465, Korea
Jong-Heon Park: National Health Insurance Service, Wonju 26464, Korea
Min Kyung Hyun: Department of Preventive Medicine, College of Korean Medicine, Dongguk University, Gyeongju-si 38066, Korea

IJERPH, 2021, vol. 18, issue 4, 1-12

Abstract: This retrospective cohort study was done to investigate the incidence of hypertension and its relation to the fasting blood glucose level in Korea. The eligible non-hypertensive subjects ( n = 3,396,187) among the National Health Insurance Service-National Health Screening (NHIS-HEALS) examinees ( n = 10,644,911) in 2009 were followed up until 2015. A Cox proportional hazards regression was used to estimate the risk of the high blood glucose level for the incident hypertension while controlling for covariates’ confounding effect. The cumulative incidence rate was 10.6% for seven years (11.6% in men and 8.3% in women). The incidence density was 1474.8 per 100,000 person-years. High fasting blood glucose (adjusted Hazard Ratio (aHR), 1.836; 95% confidence interval (CI), 1.810 to 1.862), prediabetes (aHR, 1.249; 95% CI, 1.237 to 1.260), a history of diabetes mellitus (aHR, 1.635; 95% CI, 1.605 to 1.666), high triglyceride (aHR, 1.292; 95% CI, 1.280 to 1.303), a history of dyslipidemia (aHR, 1.279; 95% CI, 1.253 to 1.305) and prehypertension group (aHR, 1.964; 95% CI, 1.948 to 1.979) were significantly related to the incident hypertension after adjusting for covariates. Among real-world data in Korea, high blood glucose level was the independent risk factor for developing hypertension.

Keywords: incidence; hypertension; blood glucose; prediabetic state; prehypertension (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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