Analgesic Opioid Misuse and Opioid Use Disorder among Patients with Chronic Non-Cancer Pain and Prescribed Opioids in a Pain Centre in France

Morgane Guillou-Landreat, Bertrand Quinio, Jean Yves Le Reste, Delphine Le Goff, Jérôme Fonsecca, Marie Grall-Bronnec and Antoine Dany
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Morgane Guillou-Landreat: INSERM UMR 1246, SPHERE, Methods in Patient-Centered Outcomes and Health Research, Nantes and Tours Universities, 44000 Nantes, France
Bertrand Quinio: CHRU, Hopital de la Cavale Blanche, 29200 Brest, France
Jean Yves Le Reste: EA 7479 SPURBO, BREST University, 29200 Brest, France
Delphine Le Goff: EA 7479 SPURBO, BREST University, 29200 Brest, France
Jérôme Fonsecca: EA 7479 SPURBO, BREST University, 29200 Brest, France
Marie Grall-Bronnec: INSERM UMR 1246, SPHERE, Methods in Patient-Centered Outcomes and Health Research, Nantes and Tours Universities, 44000 Nantes, France
Antoine Dany: EA 7479 SPURBO, BREST University, 29200 Brest, France

IJERPH, 2021, vol. 18, issue 4, 1-15

Abstract: (1) Background: Chronic non-cancer pain (CNCP) remains a public health challenge around the world. Opioids (PO) have been increasingly used in the treatment of CNCP in the last 20 years. This study aimed to assess the prevalence of opioid misuse and prescribed-opioid use disorder (p-OUD) among patients with CNCP in a pain centre in France, and to analyse risk factors for moderate or severe p-OUD. (2) Method: A cross-sectional study was conducted, including patients consulting for pain management in the pain centre of Brest University Hospital. A self-questionnaire was administered (sociodemographic data, medical data, PO misuse, and p-OUD according the Diagnostic and Statistical Manual of Mental Disorders 5 (DSM 5) criteria). Descriptive, univariate, and multivariate analyses were conducted, together with a principal component analysis, in order to identify factors associated with p-OUD. (3) Results: In total, 115 patients were included, the majority of whom were women, with a mean age of 52 years old [18–82]; 64.3% ( n = 74) had a current prescription for opioid analgesics (weak or strong). In this group, 56.7% ( n = 42) had no or only mild p-OUD and 43.3% ( n = 32) had current moderate or severe p-OUD. Patients with moderate or severe p-OUD were more likely to have a current antidepressant prescription, to have had psychotherapy, to currently use strong opioids and oxycodone, and to report taking more frequent doses than prescribed and feeling dependent. (4) Conclusions: We showed that the prevalence of current moderate/severe p-OUD concerned 43.3% of the patients with a CNCP seeking treatment in a pain centre. According to these results, several measures are relevant in managing p-OUD among patients with CNCP.

Keywords: prescribed opioids; opioid misuse; opioid use disorder; chronic non-cancer pain (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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