Preterm Deliveries in Women with Uterine Myomas: The Japan Environment and Children’s Study

Tsuyoshi Murata, Hyo Kyozuka, Yuta Endo, Toma Fukuda, Shun Yasuda, Akiko Yamaguchi, Akiko Sato, Yuka Ogata, Kosei Shinoki, Mitsuaki Hosoya, Seiji Yasumura, Koichi Hashimoto, Hidekazu Nishigori, Keiya Fujimori and The Japan Environment Children’s Study (JECS) Group
Additional contact information
Tsuyoshi Murata: Fukushima Regional Center for the Japan Environment and Children’s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan
Hyo Kyozuka: Fukushima Regional Center for the Japan Environment and Children’s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan
Yuta Endo: Fukushima Regional Center for the Japan Environment and Children’s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan
Toma Fukuda: Fukushima Regional Center for the Japan Environment and Children’s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan
Shun Yasuda: Fukushima Regional Center for the Japan Environment and Children’s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan
Akiko Yamaguchi: Fukushima Regional Center for the Japan Environment and Children’s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan
Akiko Sato: Fukushima Regional Center for the Japan Environment and Children’s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan
Yuka Ogata: Fukushima Regional Center for the Japan Environment and Children’s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan
Kosei Shinoki: Fukushima Regional Center for the Japan Environment and Children’s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan
Mitsuaki Hosoya: Fukushima Regional Center for the Japan Environment and Children’s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan
Seiji Yasumura: Fukushima Regional Center for the Japan Environment and Children’s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan
Koichi Hashimoto: Fukushima Regional Center for the Japan Environment and Children’s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan
Hidekazu Nishigori: Fukushima Regional Center for the Japan Environment and Children’s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan
Keiya Fujimori: Fukushima Regional Center for the Japan Environment and Children’s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan
The Japan Environment Children’s Study (JECS) Group: Membership of the Japan Environment and Children’s Study (JECS) Group is provided in the Acknowledgments

IJERPH, 2021, vol. 18, issue 5, 1-9

Abstract: This study aimed to clarify the association between uterine myomas and preterm birth (PTB), preterm premature rupture of membranes (pPROM), and intrauterine infection (II). The study was based on data from the Japan Environment and Children’s Study, a nationwide birth-cohort study. Data of 86,370 women with singleton births after 22 weeks of gestation (with uterine myomas, n = 5354) were retrospectively analyzed. Using logistic regression, adjusted odds ratios (aORs) for PTB, pPROM, and II were calculated considering women without uterine myomas as the reference. Additionally, the effects of II on the incidence of PTB and pPROM were evaluated. In women with uterine myomas, the aORs for PTB before 37 and 34 weeks, pPROM, and II were 1.37 (95% confidence interval, 1.22–1.54), 1.61 (1.27–2.05), 1.65 (1.33–2.04), and 1.05 (0.75–1.46), respectively. The aORs for PTB and pPROM in women with II and uterine myomas were not significantly increased. Uterine myomas during pregnancy were associated with an increased incidence of PTB and pPROM. However, II in women with uterine myomas was not associated with an increased incidence of PTB or pPROM. These findings suggest a potential risk of occult PTB in pregnant women with uterine myomas.

Keywords: birth-cohort study; uterine myoma; preterm birth; preterm premature rupture of membranes; intrauterine infection (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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