The Association of Bisphenol A and Phthalates with Risk of Breast Cancer: A Meta-Analysis

Ge Liu, Wei Cai, Huan Liu, Haihong Jiang, Yongyi Bi and Hong Wang
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Ge Liu: Department of Occupational and Environmental Health, School of Health Sciences, Wuhan University, Wuhan 430071, China
Wei Cai: Department of Occupational and Environmental Health, School of Health Sciences, Wuhan University, Wuhan 430071, China
Huan Liu: Department of Occupational and Environmental Health, School of Health Sciences, Wuhan University, Wuhan 430071, China
Haihong Jiang: Department of Occupational and Environmental Health, School of Health Sciences, Wuhan University, Wuhan 430071, China
Yongyi Bi: Department of Occupational and Environmental Health, School of Health Sciences, Wuhan University, Wuhan 430071, China
Hong Wang: Department of Occupational and Environmental Health, School of Health Sciences, Wuhan University, Wuhan 430071, China

IJERPH, 2021, vol. 18, issue 5, 1-16

Abstract: Background: Breast cancer is the most common cancer and the second leading cause of cancer-related death amongst American women. Endocrine-disrupting chemicals (EDCs), especially bisphenol A (BPA) and phthalates, have adverse effects on human health. However, the association of BPA and phthalates with breast cancer remains conflicting. This study aims to investigate the association of BPA and phthalates with breast cancer. Methods: Correlative studies were identified by systematically searching three electronic databases, namely, PubMed, Web of Sciences, and Embase, up to November 2020. All data were analyzed using Stata 15.0. Results: A total of nine studies, consisting of 7820 breast cancer cases and controls, were included. The urinary phthalate metabolite mono-benzyl phthalate (MBzP) and mono-2-isobutyl phthalate (MiBP) were negatively associated with breast cancer (OR = 0.73, 95% CI: 0.60–0.90; OR = 0.75, 95% CI: 0.58–0.98, respectively). However, the overall ORs for BPA, mono-ethyl phthalate (MEP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-2-ethylhexyl phthalate (MEHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-(3-carboxypropyl) phthalate (MCPP), and mono-butyl phthalate (MBP) were 0.85 (95% CI: 0.69–1.05), 0.96 (95% CI: 0.62–1.48), 1.12 (95% CI: 0.88–1.42), 1.13 (95% CI: 0.74–1.73), 1.01 (95% CI: 0.74–1.40), 0.74 (95% CI: 0.48–1.14), and 0.80 (95% CI: 0.55–1.15), respectively, suggesting no significant association. The sensitivity analysis indicated that the results were relatively stable. Conclusion: Phthalate metabolites MBzP and MiBP were passively associated with breast cancer, whereas no associations were found between BPA, MEP, MEHHP, MEHP, MEOHP, MCPP, and MBP and breast cancer. More high-quality case-control studies or persuasive cohort studies are urgently needed to draw the best conclusions.

Keywords: bisphenol A; phthalates; endocrine-disrupting chemicals; breast cancer; meta-analysis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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