Evaluation of Galectin-3 Plasma Concentration in Adolescents with Ventricular Arrhythmia

Radosław Pietrzak, Tomasz M. Książczyk, Elżbieta Górska, Łukasz A. Małek and Bożena Werner
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Radosław Pietrzak: Department of Pediatric Cardiology and General Pediatrics, Medical University of Warsaw, Żwirki i Wigury Street 63a, 02-091 Warsaw, Poland
Tomasz M. Książczyk: Department of Pediatric Cardiology and General Pediatrics, Medical University of Warsaw, Żwirki i Wigury Street 63a, 02-091 Warsaw, Poland
Elżbieta Górska: Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Żwirki i Wigury Street 63a, 02-091 Warsaw, Poland
Łukasz A. Małek: Department of Epidemiology, Cardiovascular Disease Prevention and Health Promotion, National Institute of Cardiology, Alpejska Street 42, 04-628 Warsaw, Poland
Bożena Werner: Department of Pediatric Cardiology and General Pediatrics, Medical University of Warsaw, Żwirki i Wigury Street 63a, 02-091 Warsaw, Poland

IJERPH, 2021, vol. 18, issue 5, 1-11

Abstract: Galectin-3 (G3) is a biomarker known as an inflammatory state exponent. The aim of this paper was to analyze the G3 in adolescents with ventricular arrhythmia (VES) in order to evaluate its impact on myocardial tissue preservation. The study group (SG) consisted of 25 VES adolescents. The control group (CG) was 21 healthy children. G3 was assessed in the SG and CG. In the SG electrocardiography, Holter monitoring, echocardiography and CMR were performed. The G3 in SG was 13.45 ± 11.4 ng/mL and in CG 7.2 ± 2.0 ng/mL, p < 0.001. Moderate positive correlation between the G3 and z-score of the left ventricular diameter (r = 0.47, p = 0.041) and moderate negative correlation between the G3 and the left ventricular ejection fraction in cardiac magnetic resonance (CMR EF) (?0.49, p = 0.032) were found. According to the multiple linear regression analysis, CMR EF and VES were independent predictors for G3 elevation. Conclusion: Galectin-3 plasma concentration is elevated and correlates with the chosen left ventricular dysfunction parameters in adolescents suffering from ventricular arrhythmia. Further investigation is necessary to establish if elevated G3 is a useful biomarker for screening young individuals with ventricular arrhythmia who are at risk of structural cardiovascular pathology.

Keywords: galectin-3; ventricular arrhythmia; adolescents (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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