Visual Parameters and Retinal Morphology for Polypoidal Choroidal Vasculopathy Pre- and Post-Intravitreal Ranibizumab with or without Photodynamic Therapy: A Short-Term Prospective Study

Rituparna Ghoshal, Sharanjeet Sharanjeet-Kaur, Norliza Mohamad Fadzil, Somnath Ghosh, Nor Fariza Ngah and Roslin Azni Binti Abd Aziz
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Rituparna Ghoshal: Optometry & Vision Science Program, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
Sharanjeet Sharanjeet-Kaur: Optometry & Vision Science Program, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
Norliza Mohamad Fadzil: Optometry & Vision Science Program, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
Somnath Ghosh: Department of Allied Health Sciences, Brainware University, Barasat, Kalkata, West Bengal 700125, India
Nor Fariza Ngah: Department of Ophthalmology, Hospital Shah Alam, Persiaran Kayangan, Seksyen 7, Shah Alam 40000, Malaysia
Roslin Azni Binti Abd Aziz: Department of Ophthalmology, Hospital Shah Alam, Persiaran Kayangan, Seksyen 7, Shah Alam 40000, Malaysia

IJERPH, 2021, vol. 18, issue 5, 1-10

Abstract: The objective of this study was to compare visual parameters and retinal layers’ morphology pre-treatment (baseline) and 6 months post-treatment in polypoidal choroidal vasculopathy (PCV) eyes. A single centre, longitudinal, prospective study was conducted at a public tertiary hospital of Malaysia. Visual parameters including distance and near visual acuity (DVA and NVA), contrast sensitivity (CS), reading speed (RS), and different qualitative and quantitative optical coherence tomography (OCT) parameters were evaluated pre- and 6 months post-treatment. Thirty-three naïve PCV eyes of 32 patients (mean age of 67.62 years) were evaluated pre- and post-treatment of intravitreal ranibizumab with and without photodynamic therapy. After treatment, sub retinal fluid decreased from 27 eyes (84.35%) at baseline to 7 eyes (21.88%) at 6 months while pigment epithelium detachment decreased from 32 eyes (100%) at base line to 15 eyes (46.87%) at 6 months. Mean pre-treatment quantitative morphological OCT retinal parameters including thickness and volume of central sub field, center thickness, center minimum, and maximum thickness reduced significantly. Similarly, all visual parameters including DVA, NVA, CS, and RS showed statistically significant improvement. While 89% of the eyes showed improvement in CS, 78%, 71%, and 65% of the eyes showed improvement in NVA, RS, and DVA, respectively. Thus, CS was the most treatment responsive visual parameter.

Keywords: combination therapy; polypoidal choroidal vasculopathy; retinal morphology; visual functions (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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