Six-Minute Walk Distance in Breast Cancer Survivors—A Systematic Review with Meta-Analysis

Jasna But-Hadzic, Mirza Dervisevic, Damir Karpljuk, Mateja Videmsek, Edvin Dervisevic, Armin Paravlic, Vedran Hadzic and Katja Tomazin
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Jasna But-Hadzic: Department of Radiation Oncology, Institute of Oncology, 1000 Ljubljana, Slovenia
Mirza Dervisevic: Faculty of Sport, University of Ljubljana, 1000 Ljubljana, Slovenia
Damir Karpljuk: Faculty of Sport, University of Ljubljana, 1000 Ljubljana, Slovenia
Mateja Videmsek: Faculty of Sport, University of Ljubljana, 1000 Ljubljana, Slovenia
Edvin Dervisevic: Faculty of Sport, University of Ljubljana, 1000 Ljubljana, Slovenia
Armin Paravlic: Faculty of Sport, University of Ljubljana, 1000 Ljubljana, Slovenia
Vedran Hadzic: Faculty of Sport, University of Ljubljana, 1000 Ljubljana, Slovenia
Katja Tomazin: Faculty of Sport, University of Ljubljana, 1000 Ljubljana, Slovenia

IJERPH, 2021, vol. 18, issue 5, 1-13

Abstract: The six-minute walk test (6MWT) is a widely used test for the indirect measurement of cardiorespiratory fitness in various cancer populations. Although the 6MWT is a simple test, there are no normative values for breast cancer survivors (BCS) or comparisons of results with healthy counterparts. A systematic review with a meta-analysis was carried out, which included studies from 2007 to 2020. Ninety-one studies were found, 21 of which were included in the quantitative synthesis. Among them were 9 randomized controlled trials (RCT), 8 prospective cohort studies and 4 cross-sectional studies. A total of 1084 BCS were included. Our results revealed that healthy subjects (n = 878) covered a significantly greater distance than BCS during the 6MWT (589.9 m vs. 477.4 m, p < 0.001), and the results of the meta-regression analysis showed that the 6MWD was predicted by the participants’ BMI ( p < 0.001), but not by their age ( p = 0.070). After adjustment for BMI, the healthy subjects also covered greater distances than the BCS (103 m; p < 0.001). The normative values of 6MWT were presented for BCS. Besides, 6MWT distances distinguish between their healthy counterparts, therefore, the 6MWT distance is a relevant parameter for the assessment and monitoring of cardiorespiratory fitness in medical and exercise interventions for BCS.

Keywords: female; cardio-respiratory fitness; reference values; breast cancer; six minute walk test (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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