Incidence of Pregnancy-Associated Cancer in Two Canadian Provinces: A Population-Based Study

Amy Metcalfe, Zoe F. Cairncross, Christine M. Friedenreich, Joel G. Ray, Gregg Nelson, Deshayne B. Fell, Sarka Lisonkova, Parveen Bhatti, Carly McMorris, Khokan C. Sikdar and Lorraine Shack
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Amy Metcalfe: Department of Obstetrics and Gynecology, University of Calgary, Calgary, AB T2N 1N4, Canada
Zoe F. Cairncross: Department of Obstetrics and Gynecology, University of Calgary, Calgary, AB T2N 1N4, Canada
Christine M. Friedenreich: Department of Community Health Sciences, University of Calgary, Calgary, AB T2N 1N4, Canada
Joel G. Ray: Department of Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada
Gregg Nelson: Department of Obstetrics and Gynecology, University of Calgary, Calgary, AB T2N 1N4, Canada
Deshayne B. Fell: School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON K1N 6N5, Canada
Sarka Lisonkova: Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
Parveen Bhatti: Cancer Control Research, BC Cancer, Vancouver, BC V5Z 1G1, Canada
Carly McMorris: Werkland School of Education, University of Calgary, Calgary, AB T2N 1N4, Canada
Khokan C. Sikdar: Department of Community Health Sciences, University of Calgary, Calgary, AB T2N 1N4, Canada
Lorraine Shack: Department of Community Health Sciences, University of Calgary, Calgary, AB T2N 1N4, Canada

IJERPH, 2021, vol. 18, issue 6, 1-7

Abstract: Pregnancy-associated cancer—that is diagnosed in pregnancy or within 365 days after delivery—is increasingly common as cancer therapy evolves and survivorship increases. This study assessed the incidence and temporal trends of pregnancy-associated cancer in Alberta and Ontario—together accounting for 50% of Canada’s entire population. Linked data from the two provincial cancer registries and health administrative data were used to ascertain new diagnoses of cancer, livebirths, stillbirths and induced abortions among women aged 18–50 years, from 2003 to 2015. The annual crude incidence rate (IR) was calculated as the number of women with a pregnancy-associated cancer per 100,000 deliveries. A nonparametric test for trend assessed for any temporal trends. In Alberta, the crude IR of pregnancy-associated cancer was 156.2 per 100,000 deliveries (95% CI 145.8–166.7), and in Ontario, the IR was 149.4 per 100,000 deliveries (95% CI 143.3–155.4). While no statistically significant temporal trend in the IR of pregnancy-associated cancer was seen in Alberta, there was a rise in Ontario ( p = 0.01). Pregnancy-associated cancer is common enough to warrant more detailed research on maternal, pregnancy and child outcomes, especially as cancer therapies continue to evolve.

Keywords: cancer incidence rate; pregnancy-associated cancer; temporal trends; epidemiology; pregnancy; obstetrics; data linkage; novel use of cancer registry (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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