Comparison of Bone Tissue Trace Element Content in the Different Radiological Stages of Hip Osteoarthritis

Mikołaj Dąbrowski, Anetta Zioła-Frankowska, Marcin Frankowski, Jacek Kaczmarczyk and Łukasz Kubaszewski
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Mikołaj Dąbrowski: Adult Spine Orthopaedics Department, Poznan University of Medical Sciences, 61-545 Poznan, Poland
Anetta Zioła-Frankowska: Department of Analytical Chemistry, Faculty of Chemistry, Adam Mickiewicz University in Poznan, 61-614 Poznan, Poland
Marcin Frankowski: Department of Analytical and Environmental Chemistry, Faculty of Chemistry, Adam Mickiewicz University in Poznan, 61-614 Poznan, Poland
Jacek Kaczmarczyk: Poznan LAB, Institute of Practical Medicine, 62-081 Przezmierowo, Poland
Łukasz Kubaszewski: Adult Spine Orthopaedics Department, Poznan University of Medical Sciences, 61-545 Poznan, Poland

IJERPH, 2021, vol. 18, issue 6, 1-9

Abstract: Bone metabolism and the trace element content associated with it change at each stage of degenerative disease. The aim of this study was to find out about the role of the analyzed elements in different stages of hip osteoarthritis. Elements associated with oxidative and enzymatic processes were analyzed depending on the changes in the radiological images of the hip joint. Element content analysis was performed by the inductively coupled plasma mass spectrometry analytical technique. The femoral head in severely osteoarthritic hips (KL3–4) compared to mild grade osteoarthritis (KL2) had a greater content of Cu (median 1.04 vs. 0.04), Sr (median 38.71 vs. 29.59), and Zn (median 75.12 vs. 63.21). There were no significant differences in the content of Mo, Cr, and Fe in the femoral head and neck between the groups. The Cu/Fe correlation was negative in the KL2 group (?0.47) and positive in the KL3–4 groups (0.45). Changes in the content and correlation of trace elements in the hip joint explain the changes in metabolism dependent on the severity of degenerative changes.

Keywords: trace elements; metalloproteinase; femoral bone; hip osteoarthritis stages; grades (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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