Biocompatibility and Effectiveness of a Novel, Organic Olive Oil-Based Denture Adhesive: A Multicenter Randomized and Placebo-Controlled Clinical Trial

Luís Azevedo, André Correia, Carlos F. Almeida, Pedro Molinero-Mourelle, Maria Correia and Jaime Del Río Highsmith
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Luís Azevedo: Department of Conservative Dentistry and Orofacial Prosthodontics, Faculty of Dentistry, Complutense University of Madrid, 28040 Madrid, Spain
André Correia: Centre for Interdisciplinary Research in Health, Faculty of Dental Medicine, Universidade Católica Portuguesa, 3504 Viseu, Portugal
Carlos F. Almeida: Centre for Interdisciplinary Research in Health, Faculty of Dental Medicine, Universidade Católica Portuguesa, 3504 Viseu, Portugal
Pedro Molinero-Mourelle: Department of Conservative Dentistry and Orofacial Prosthodontics, Faculty of Dentistry, Complutense University of Madrid, 28040 Madrid, Spain
Maria Correia: Centre for Interdisciplinary Research in Health, Faculty of Dental Medicine, Universidade Católica Portuguesa, 3504 Viseu, Portugal
Jaime Del Río Highsmith: Department of Conservative Dentistry and Orofacial Prosthodontics, Faculty of Dentistry, Complutense University of Madrid, 28040 Madrid, Spain

IJERPH, 2021, vol. 18, issue 7, 1-11

Abstract: To assess the clinical efficacy of a novel, organic olive oil-based denture adhesive and its effect on Candida albicans growth in maxillary edentulous individuals wearing complete dentures, individuals were selected from two dental schools in Portugal and Spain. Twenty-eight complete dentures were relined, following a standardized protocol. The novel product (test) was compared with a commercialized adhesive (control) and Vaseline (placebo) randomly assigned in a cross-study design. The retention resistance was measured with a gnathometer and a dynamometer. The patients related outcome evaluations with a five-point questionnaire, and the Candida albicans growth in a Sabouraud dextrose agar (SDA) medium was used to evaluate differences between the placebo and experimental product. Twenty-three participants were included. The dynamometer evaluation showed significant differences between not using a denture adhesive and using either (experimental, p = 0.03; control, p = 0.04) and no significant differences between the two adhesives ( p > 0.05). In the subjective analysis, the experimental adhesive showed a significantly longer effectiveness ( p = 0.001), and the control reported better results in taste ( p = 0.03) and in chewing ( p = 0.001). The test adhesive showed better ( p < 0.001) Candida albicans growth inhibition. The experimental adhesive showed longer effectiveness than the control and the placebo with a better inhibition capacity for the growth of Candida albicans . Patients reported better abilities for speech, chewing, taste, and retirement in the control adhesive.

Keywords: prosthodontics; edentulism; elderly; complete dentures; Candida albicans; antimicrobial activity (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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