Glycaemic Variability and Risk Factors of Pregnant Women with and without Gestational Diabetes Mellitus Measured by Continuous Glucose Monitoring

Martina Gáborová, Viera Doničová, Ivana Bačová, Mária Pallayová, Martin Bona, Igor Peregrim, Soňa Grešová, Judita Štimmelová, Barbora Dzugasová, Lenka Šalamonová Blichová and Viliam Donič
Additional contact information
Martina Gáborová: Department of Medical Physiology, Faculty of Medicine, Pavol Jozef Safarik University, 040 11 Košice, Slovakia
Viera Doničová: Internal and Diabetology Outpatient Department, Human-Care s.r.o., Affiliated Study Foundation for Faculty of Medicine, Pavol Jozef Safarik University, 040 11 Košice, Slovakia
Ivana Bačová: Department of Medical Physiology, Faculty of Medicine, Pavol Jozef Safarik University, 040 11 Košice, Slovakia
Mária Pallayová: Department of Medical Physiology, Faculty of Medicine, Pavol Jozef Safarik University, 040 11 Košice, Slovakia
Martin Bona: Department of Medical Physiology, Faculty of Medicine, Pavol Jozef Safarik University, 040 11 Košice, Slovakia
Igor Peregrim: Department of Medical Physiology, Faculty of Medicine, Pavol Jozef Safarik University, 040 11 Košice, Slovakia
Soňa Grešová: Department of Medical Physiology, Faculty of Medicine, Pavol Jozef Safarik University, 040 11 Košice, Slovakia
Judita Štimmelová: Department of Medical Physiology, Faculty of Medicine, Pavol Jozef Safarik University, 040 11 Košice, Slovakia
Barbora Dzugasová: Department of Medical and Clinical Microbiology, Faculty of Medicine, Pavol Jozef Safarik University, 040 11 Košice, Slovakia
Lenka Šalamonová Blichová: Department of Pathological Physiology, Faculty of Medicine, Pavol Jozef Safarik University, 040 11 Košice, Slovakia
Viliam Donič: Department of Medical Physiology, Faculty of Medicine, Pavol Jozef Safarik University, 040 11 Košice, Slovakia

IJERPH, 2021, vol. 18, issue 7, 1-10

Abstract: Background : The aim of the study was to compare the continuous glucose monitoring (CGM)-determined glycaemic variability (GV) of pregnant women with gestational diabetes mellitus (GDM) and without GDM (CG; control group). The secondary aim was to evaluate the association between risk factors of diabetes in pregnancy and parameters of glyceamic control. Methods : Demographic, biometric and biochemical parameters were obtained for pregnant women (20–38 years old) who after an oral glucose tolerance test were examined by 7-day continuous glucose monitoring using a iPro ® 2 Professional CGM. Results : The differences in GV between women with GDM and CG compared by total area under glucose curve (total AUC, (mmol·day/L) was statistically significant ( p = 0.006). Other parameters of glycaemic control such as mean glucose, standard deviation, coefficient of variation, J-index, % time-above target range 7.8 mmol/L (%TAR), % time-in range 3.5–7.8 mmol/L (%TIR), time-below target range 3.5 mmol/L (%TBR), glycated haemoglobin were not significantly different in the study groups. Risk factors (a family history of diabetes, pre-pregnancy BMI, higher weight gain and age) correlated with parameters of glycaemic control. Conclusions : We found a significant difference in GV of women with and without GDM by total AUC determined from CGM. TIR metrics were close to significance. Our work points at an increased GV in relation to the risk factors of GDM. Pregnant women with risk factors have higher probability of severe GV with its consequences on maternal and fetal health state.

Keywords: continuous glucose monitoring; gestational diabetes mellitus; glycaemic variability; risk factors (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/18/7/3402/pdf (application/pdf)
https://www.mdpi.com/1660-4601/18/7/3402/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:18:y:2021:i:7:p:3402-:d:523925

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().