Serum Levels of Fibroblast Growth Factor 21 Are Positively Associated with Aortic Stiffness in Patients with Type 2 Diabetes Mellitus

Sin-Yi Huang, Du-An Wu, Jen-Pi Tsai and Bang-Gee Hsu
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Sin-Yi Huang: Department of General Practice, Far Eastern Memorial Hospital, New Taipei City 22016, Taiwan
Du-An Wu: School of Medicine, Tzu-Chi University, Hualien 970374, Taiwan
Jen-Pi Tsai: School of Medicine, Tzu-Chi University, Hualien 970374, Taiwan
Bang-Gee Hsu: School of Medicine, Tzu-Chi University, Hualien 970374, Taiwan

IJERPH, 2021, vol. 18, issue 7, 1-9

Abstract: Aortic stiffness (AS), assessed using carotid–femoral pulse wave velocity (cfPWV), is associated with cardiovascular disease in type 2 diabetes mellitus (T2DM). The relationship between serum fibroblast growth factor 21 (FGF-21) and AS in T2DM patients was evaluated. Fasting serum FGF-21 levels of 130 T2DM patients were measured using an enzyme immunoassay kit. A validated tonometry system was used to measure cfPWV (>10 m/s indicated AS). Of these T2DM patients, 34.6% were defined as the AS group. T2DM patients with AS were older; exhibited higher systolic blood pressure, diastolic blood pressure, and body fat mass; higher triglyceride, fasting glucose, glycosylated hemoglobin, and creatinine levels; higher urine albumin-to-creatinine ratios and serum FGF-21 levels; and lower estimated glomerular filtration rates. The FGF-21 level (odds ratio = 1.005, 95% confidence interval: 1.002–1.009, p = 0.002) as well as systolic blood pressure was an independent predictor of AS and positively correlated to cfPWV values (? = 0.369, p < 0.001) in T2DM patients. For T2DM patients, serum FGF-21 level could be a predictor for AS.

Keywords: aortic stiffness; fibroblast growth factor 21; carotid–femoral pulse wave velocity; type 2 diabetes mellitus (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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