Solitary Extramedullary Plasmacytoma Presenting as Asymptomatic Palatal Erythroplakia: Report of a Case

Francesca Lalla, Alessandro Vinciguerra, Alessandra Lissoni, Gianluigi Arrigoni, Francesca Lira Luce and Silvio Abati
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Francesca Lalla: Otorhinolaryngology—Head & Neck Surgery Department, San Raffaele Hospital, University Vita-Salute, 20132 Milan, Italy
Alessandro Vinciguerra: Otorhinolaryngology—Head & Neck Surgery Department, San Raffaele Hospital, University Vita-Salute, 20132 Milan, Italy
Alessandra Lissoni: Department of Dentistry and Stomatology IRCCS San Raffaele Hospital, University Vita-Salute, 20132 Milan, Italy
Gianluigi Arrigoni: Department of Anatomic Pathology, San Raffaele Hospital, University Vita-Salute, 20132 Milan, Italy
Francesca Lira Luce: Otorhinolaryngology—Head & Neck Surgery Department, San Raffaele Hospital, University Vita-Salute, 20132 Milan, Italy
Silvio Abati: School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy

IJERPH, 2021, vol. 18, issue 7, 1-7

Abstract: Solitary plasmacytoma (SP) is a rare malignant tumor of plasma cells with no systemic spread; however, when it disseminates and affects multiple skeletal sites, it is called multiple myeloma (MM). The etiology of solitary plasmacytoma is unknown, with two possible subtypes: solitary extramedullary plasmacytoma (EMP) and solitary bone plasmacytoma (SBP). We present a case of EMP arising as asymptomatic erythroplakia of the palate, which is rarely described in the literature. The definitive diagnosis was obtained with immunohistochemical studies, after which the lesion was subjected to excisional biopsy. At present, after two years of close follow-up, the patient has shown no signs of relapse or conversion to MM. The uniqueness of the case highlights the possibility of an atypical EMP lesion in the head and neck, thus posing a diagnostic and therapeutic challenge for physicians.

Keywords: multiple myeloma; extramedullary plasmacytoma; oral pathology; oral health (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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