A Review of the Role of Endo/Sarcoplasmic Reticulum-Mitochondria Ca 2+ Transport in Diseases and Skeletal Muscle Function

Shuang-Shuang Zhang, Shi Zhou, Zachary J. Crowley-McHattan, Rui-Yuan Wang and Jun-Ping Li
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Shuang-Shuang Zhang: School of Sport Science, Beijing Sport University, Beijing 100084, China
Shi Zhou: Faculty of Health, Southern Cross University, East Lismore, NSW 2480, Australia
Zachary J. Crowley-McHattan: Faculty of Health, Southern Cross University, East Lismore, NSW 2480, Australia
Rui-Yuan Wang: School of Sport Science, Beijing Sport University, Beijing 100084, China
Jun-Ping Li: School of Sport Science, Beijing Sport University, Beijing 100084, China

IJERPH, 2021, vol. 18, issue 8, 1-12

Abstract: The physical contact site between a mitochondrion and endoplasmic reticulum (ER), named the mitochondria-associated membrane (MAM), has emerged as a fundamental platform for regulating the functions of the two organelles and several cellular processes. This includes Ca 2+ transport from the ER to mitochondria, mitochondrial dynamics, autophagy, apoptosis signalling, ER stress signalling, redox reaction, and membrane structure maintenance. Consequently, the MAM is suggested to be involved in, and as a possible therapeutic target for, some common diseases and impairment in skeletal muscle function, such as insulin resistance and diabetes, obesity, neurodegenerative diseases, Duchenne muscular dystrophy, age-related muscle atrophy, and exercise-induced muscle damage. In the past decade, evidence suggests that alterations in Ca 2+ transport from the ER to mitochondria, mediated by the macromolecular complex formed by IP 3 R, Grp75, and VDAC1, may be a universal mechanism for how ER-mitochondria cross-talk is involved in different physiological/pathological conditions mentioned above. A better understanding of the ER (or sarcoplasmic reticulum in muscle)-mitochondria Ca 2+ transport system may provide a new perspective for exploring the mechanism of how the MAM is involved in the pathology of diseases and skeletal muscle dysfunction. This review provides a summary of recent research findings in this area.

Keywords: mitochondria-associated membrane; endo/sarcoplasmic reticulum-mitochondria Ca 2+ transport; mitochondrial calcium overload; skeletal muscle function (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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