Histomorphometric Comparison between Two Types of Acellular Dermal Matrix Grafts: A Mini Pig Animal Model Study

Javier Aragoneses, Ana Suárez, Cinthia Rodríguez and Juan Manuel Aragoneses
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Javier Aragoneses: Department of Medicine and Medical Specialties, Faculty of Health Sciences, University of Alcalá, 28871 Alcalá de Henares, Spain
Ana Suárez: Department of Preclinical Dentistry, School of Biomedical Sciences, Universidad Europea de Madrid, 28670 Villaviciosa de Odón, Spain
Cinthia Rodríguez: Department of Dentistry, Federico Henriquez y Carvajal University, 11005 Santo Domingo, Dominican Republic
Juan Manuel Aragoneses: Faculty of Dentistry, Universidad Alfonso X El Sabio, 28961 Villanueva de la Cañada, Spain

IJERPH, 2021, vol. 18, issue 8, 1-15

Abstract: Acellular dermal matrix grafts (ADMG) have been used as soft tissue graft substitutes for autografts in periodontal plastic surgical procedures. They have benefits like avoiding a second surgical site and patient morbidity that have been associated with autografts, but there is limited evidence available on their tissue response and wound healing process. This histomorphometric animal model study was carried out in mini pigs and it aimed to compare the two types of ADMG materials of porcine derivative with a control group through observation of parameters like epithelial and Keratinized layer thickness, angiogenesis, cellularity, matrix resorption, and inflammatory infiltrate. The surgical technique involved punctures on the edentulous areas stripping the epithelial tissue and exposing the underlying connective tissue, placement of the ADMGs in the appropriate control and test sites. Following this, gingival biopsies were procured at three different time intervals of 15, 45, and 90 days. There were significant differences in epithelial and Keratinized layer thickness among the three groups. This study concluded that there was no clear consensus on which graft material was superior but it gave an insight into the tissue response and wound healing process associated with the graft materials.

Keywords: animal model; acellular dermal matrix graft; angiogenesis; keratin; wound healing (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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