Effectiveness of Antalgic Therapies in Patients with Vertebral Bone Metastasis: A Protocol for a Systematic Review and Meta-Analysis

Antonio Jose Martin-Perez, María Fernández-González, Paula Postigo-Martin, Marc Sampedro Pilegaard, Carolina Fernández-Lao, Eduardo Castro-Martín, Lydia Martín-Martín and Mario Lozano-Lozano
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Antonio Jose Martin-Perez: Department of Internal Medicine, San Cecilio University Hospital, Hospital Universitario San Cecilio, 18016 Granada, Spain
María Fernández-González: Department of Physical Therapy, Faculty of Health Sciences, University of Granada, 18010 Granada, Spain
Paula Postigo-Martin: Biohealth Research Institute in Granada (ibs.GRANADA), 18016 Granada, Spain
Marc Sampedro Pilegaard: Occupational Science and Occupational Therapy, The Research Unit for User Perspectives and Community-Based Interventions, Department of Public Health, University of Southern Denmark, 5230 Odense, Denmark
Carolina Fernández-Lao: Biohealth Research Institute in Granada (ibs.GRANADA), 18016 Granada, Spain
Eduardo Castro-Martín: Biohealth Research Institute in Granada (ibs.GRANADA), 18016 Granada, Spain
Lydia Martín-Martín: Biohealth Research Institute in Granada (ibs.GRANADA), 18016 Granada, Spain
Mario Lozano-Lozano: Biohealth Research Institute in Granada (ibs.GRANADA), 18016 Granada, Spain

IJERPH, 2021, vol. 18, issue 8, 1-7

Abstract: There is no systematic review that has identified existing studies evaluating the pharmacological and non-pharmacological intervention for pain management in patients with bone metastasis. To fill this gap in the literature, this systematic review with meta-analysis aims to evaluate the effectiveness of different antalgic therapies (pharmacological and non-pharmacological) in the improvement of pain of these patients. To this end, this protocol has been written according to the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) and registered in PROSPERO (CRD42020135762). A systematic search will be carried out in four international databases: Medline (Via PubMed), Web of Science, Cochrane Library and SCOPUS, to select the randomized controlled clinical trials. The Risk of Bias Tool developed by Cochrane will be used to assess the risk of bias and the quality of the identified studies. A narrative synthesis will be used to describe and compare the studies, and after the data extraction, random effects model and a subgroup analyses will be performed according to the type of intervention, if possible. This protocol aims to generate a systematic review that compiles and synthesizes the best and most recent evidence on the treatment of pain derived from vertebral metastasis.

Keywords: systematic review; neoplasm metastasis; bone and bones; spine; pain; protocol (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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