Association between Triglyceride Glucose Index and Corrected QT Prolongation in Chinese Male Steelworkers

Thung-Lip Lee, Chin-Feng Hsuan, Cheng-Ching Wu, Wei-Chin Hung, I-Ting Tsai, Ching-Ting Wei, Teng-Hung Yu, I-Cheng Lu, Fu-Mei Chung, Yau-Jiunn Lee and Yung-Chuan Lu
Additional contact information
Thung-Lip Lee: Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445, Taiwan
Chin-Feng Hsuan: Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445, Taiwan
Cheng-Ching Wu: Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445, Taiwan
Wei-Chin Hung: Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445, Taiwan
I-Ting Tsai: School of Medicine, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan
Ching-Ting Wei: School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan
Teng-Hung Yu: Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445, Taiwan
I-Cheng Lu: Department of Occupational Medicine, E-Da Hospital, Kaohsiung 82445, Taiwan
Fu-Mei Chung: Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445, Taiwan
Yau-Jiunn Lee: Lee’s Endocrinologic Clinic, Pingtung 90000, Taiwan
Yung-Chuan Lu: School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan

IJERPH, 2021, vol. 18, issue 8, 1-14

Abstract: Objectives: Increased triglyceride glucose (TyG) index appears to be linked to carotid and coronary atherosclerosis and calcifications and possesses an elevated future risk of developing cardiovascular disease. Corrected QT (QTc) interval prolongation is associated with ventricular arrhythmias and sudden cardiac death, and a high prevalence of prolonged QTc interval was previously reported in blue-collar workers. The purpose of this study was to find the possible causal inter-relationship between TyG index and QTc interval in a large population of Chinese male steelworkers. Methods: A total of 3189 male workers from two steel plants were enrolled. They responded to a cross-sectional questionnaire on basic attributes and lifestyle, including sleep patterns. All workers in the two plants underwent periodic health checkups, including twelve-lead electrocardiography. Structural equation modeling (SEM) was used to assess the direct and indirect effects of TyG index on QTc interval. Results: With increasing TyG index tertile, the male steelworkers had an increased QTc interval. Applying multivariate analysis, TyG index was associated independently with the odds of QTc prolongation (adjusted odds ratio = 2.73, 95% confidence interval = 1.39–5.24, p = 0.004). SEM revealed that TyG index, hypertension, obesity, lifestyle, white blood cell (WBC) count, and liver function had statistically significant direct effects on QTc interval. Furthermore, TyG index also had an indirect effect on QTc interval through hypertension, obesity, WBC count, and liver function. Moreover, lifestyle had an indirect effect on QTc interval through TyG index. The final model explained 14% of the variability in QTc interval. Conclusions: An increased TyG index was associated with QTc interval prolongation in this study, and SEM delineated possible causal pathways and inter-relationships of the risk factors contributing to the occurrence of QTc prolongation among Chinese male steelworkers.

Keywords: triglyceride glucose index; corrected QT prolongation; inter-relationship; structural equation modeling; steelworker (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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