Effects of a Mixture of Ivy Leaf Extract and Coptidis rhizome on Patients with Chronic Bronchitis and Bronchiectasis

Goohyeon Hong, Yu-Il Kim, Seoung Ju Park, Sung Yong Lee, Jin Woo Kim, Seong Hoon Yoon, Keu Sung Lee, Min Kwang Byun, Hak-Ryul Kim and Jaeho Chung
Additional contact information
Goohyeon Hong: Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Dankook University Hospital, Dankook University College of Medicine, Cheonan 31116, Korea
Yu-Il Kim: Department of Internal Medicine, Division of Pulmonology, Chonnam National University Hospital, Chonnam 61469, Korea
Seoung Ju Park: Department of Internal Medicine, Division of Pulmonology, Allergy and Critical Care Medicine, Jeonbuk National University Medical School, Cheonbuk 54907, Korea
Sung Yong Lee: Department of Internal Medicine, Division of Pulmonology, Allergy and Critical Care Medicine, Korea University Guro Hospital, Seoul 08308, Korea
Jin Woo Kim: Department of Internal Medicine, Division of Pulmonology, College of Medicine, The Catholic University, Uijeongbu 11765, Korea
Seong Hoon Yoon: Department of Internal Medicine, Division of Pulmonology, Pusan National University Yangsan Hospital, Pusan 49241, Korea
Keu Sung Lee: Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Ajou University Hospital, Suwon 16499, Korea
Min Kwang Byun: Department of Internal Medicine, Division of Respiratory Medicine, Gangnam Severance Hospital, Seoul 06273, Korea
Hak-Ryul Kim: Department of Internal Medicine, Division of Respiratory Medicine, Wonkwang University Hospital, Iksan 54538, Korea
Jaeho Chung: Department of Internal Medicine, Division of Respiratory Medicine, Catholic Kwandong University International St. Mary’s Hospital, Incheon 22711, Korea

IJERPH, 2021, vol. 18, issue 8, 1-12

Abstract: Background: Hederacoside C from ivy leaf dry extracts (HH) and berberine from Coptidis rhizome dry extracts (CR) can be combined (HHCR) as a herbal product. Previous studies have demonstrated that HHCR has antitussive and expectorant effects in animal models of respiratory disease. However, the therapeutic effects of HHCR on respiratory diseases in humans have not been well-studied. Therefore, we aimed to clarify the effectiveness of HHCR in patients with chronic bronchitis and bronchiectasis. Methods: This was a multicenter (10 university teaching hospitals), open-label, prospective, single-arm, observational study. Consecutive patients with chronic bronchitis and bronchiectasis were included. Patients were orally treated with HHCR daily for 12 weeks. St. George’s Respiratory Questionnaire (SGRQ) scores and bronchitis severity scores (BSS) were measured at baseline and at the end of the 12-week study. Results: In total, 376 patients were enrolled, of which 304 were finally included in the study, including 236 males and 68 females with a median age of 69 years (range: 37–88 years). After 12 weeks of HHCR treatment, there was a significant improvement in SGRQ score (baseline, 32.52 ± 16.93 vs. end of study, 29.08 ± 15.16; p < 0.0001) and a significant reduction in BSS (baseline, 7.16 ± 2.63 vs. end of study, 4.72 ± 2.45; p < 0.0001). During the study, 14 patients concomitantly used an inhaled corticosteroid and 83 patients used an inhaled bronchodilator. HHCR also had significant positive effects on these patients in terms of SGRQ score and BSS. No serious adverse drug reactions occurred during HHCR treatment. Conclusions: treatment with HHCR improved the SGRQ score and BSS in patients with chronic bronchitis and bronchiectasis. HHCR may be a new therapeutic option for chronic bronchitis and bronchiectasis. Large-scale, randomized, double-blind, placebo-controlled clinical trials are warranted.

Keywords: chronic bronchitis; bronchiectasis; hederacoside C; berberine; mucolytic agent (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/18/8/4024/pdf (application/pdf)
https://www.mdpi.com/1660-4601/18/8/4024/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:18:y:2021:i:8:p:4024-:d:534266

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().