Partial-Body Cryostimulation Increases Resting Energy Expenditure in Lean and Obese Women

Massimo De Nardi, Ambra Bisio, Lucio Della Guardia, Carlo Facheris, Emanuela Faelli, Antonio La Torre, Livio Luzi, Piero Ruggeri and Roberto Codella
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Massimo De Nardi: Krioplanet Ltd., Treviglio, 24047 Bergamo, Italy
Ambra Bisio: Department of Experimental Medicine, Università Degli Studi di Genova, 16132 Genoa, Italy
Lucio Della Guardia: Department of Biomedical Sciences for Health, Università Degli Studi di Milano, 20133 Milano, Italy
Carlo Facheris: Krioplanet Ltd., Treviglio, 24047 Bergamo, Italy
Emanuela Faelli: Department of Experimental Medicine, Università Degli Studi di Genova, 16132 Genoa, Italy
Antonio La Torre: Department of Biomedical Sciences for Health, Università Degli Studi di Milano, 20133 Milano, Italy
Livio Luzi: Department of Biomedical Sciences for Health, Università Degli Studi di Milano, 20133 Milano, Italy
Piero Ruggeri: Department of Experimental Medicine, Università Degli Studi di Genova, 16132 Genoa, Italy
Roberto Codella: Department of Biomedical Sciences for Health, Università Degli Studi di Milano, 20133 Milano, Italy

IJERPH, 2021, vol. 18, issue 8, 1-11

Abstract: Cryostimulation is currently seen as a potential adjuvant strategy to tackle obesity and dysmetabolism by triggering cold-induced thermogenesis. Although suggestive, the underlying mechanisms are still poorly elucidated. We tested whether single or repeated applications of partial-body cryostimulation (PBC) could influence resting energy expenditure (REE) in exposed individuals. Fifteen middle-aged obese and sixteen control lean women (body mass index 31 ± 1.6 kg/m 2 and 22 ± 1.7 kg/m 2 ) underwent a daily PBC (?130 °C × 150 s) for five consecutive days. Resting energy metabolism (REE) was assessed by indirect calorimetry pre- and post-PBC on day 1 and day 5. As concerns REE, the linear mixed model revealed that REE changes were explained by session and time (F 1,29 = 5.58; p = 0.02; ? p 2 = 0.16) independent of the group (F 1,29 = 2.9; p = 0.09; ? p 2 = 0.09). REE pre-PBC increased from day 1 to day 5 either in leans (by 8.2%, from 1538 ± 111 to 1665 ± 106 kcal/day) or in obese women (by 5.5%, from 1610 ± 110 to 1698 ± 142 vs kcal/day). Respiratory quotient was significantly affected by the time (F 1,29 = 51.61; p < 0.000001, ? p 2 = 0.64), as it increased from pre- to post-PBC, suggesting a shift in substrate oxidation. According to these preliminary data, cold-induced thermogenesis could be explored as a strategy to elevate REE in obese subjects. Longitudinal studies could test whether chronic PBC effects may entail favorable metabolic adaptations.

Keywords: cold therapy; white adipose tissue; metabolism; thermogenesis; weight loss; adipocytes; indirect calorimetry; skeletal muscle; obesity treatment; brown adipose tissue (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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