Hormonal and Inflammatory Responses to Hypertrophy-Oriented Resistance Training at Acute Moderate Altitude

Cristina Benavente, Josefa León, Belén Feriche, Brad J. Schoenfeld, Juan Bonitch-Góngora, Filipa Almeida, Sergio Pérez-Regalado and Paulino Padial
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Cristina Benavente: Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, 18011 Granada, Spain
Josefa León: Clinical Management Unit of Digestive System, San Cecilio Hospital, ibs.GRANADA, 18016 Granada, Spain
Belén Feriche: Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, 18011 Granada, Spain
Brad J. Schoenfeld: Department of Health Sciences, CUNY Lehman College, Bronx, NY 10468, USA
Juan Bonitch-Góngora: Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, 18011 Granada, Spain
Filipa Almeida: Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, 18011 Granada, Spain
Sergio Pérez-Regalado: Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, 18011 Granada, Spain
Paulino Padial: Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, 18011 Granada, Spain

IJERPH, 2021, vol. 18, issue 8, 1-11

Abstract: This study investigated the effect of a traditional hypertrophy-oriented resistance training (R T ) session at acute terrestrial hypoxia on inflammatory, hormonal, and the expression of miR-378 responses associated with muscular gains. In a counterbalanced fashion, 13 resistance trained males completed a hypertrophic R T session at both moderate-altitude (H; 2320 m asl) and under normoxic conditions (N; <700 m asl). Venous blood samples were taken before and throughout the 30 min post-exercise period for determination of cytokines (IL6, IL10, TNF?), hormones (growth hormone [GH], cortisol [C], testosterone), and miR-378. Both exercise conditions stimulated GH and C release, while miR-378, testosterone, and inflammatory responses remained near basal conditions. At H, the R T session produced a moderate to large but nonsignificant increase in the absolute peak values of the studied cytokines. miR-378 revealed a moderate association with GH (r = 0.65; p = 0.026 and r = ?0.59; p = 0.051 in N and H, respectively) and C (r = 0.61; p = 0.035 and r = 0.75; p = 0.005 in N and H, respectively). The results suggest that a R T session at H does not differentially affect the hormonal, inflammatory, and miR-378 responses compared to N. However, the standardized mean difference detected values in the cytokines suggest an intensification of the inflammatory response in H that should be further investigated.

Keywords: strength; cytokines; miRNA; terrestrial altitude; hypoxia (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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