The Association between Migraine and Abdominal Aortic Aneurysms: A Nationwide Population-Based Cohort Study

Jou-Yu Lin, Che-Se Tung, Jen-Chun Wang, Wu-Chien Chien, Chi-Hsiang Chung, Chih-Yuan Lin and Shih-Hung Tsai
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Jou-Yu Lin: Department of Rehabilitation, Cheng Hsin General Hospital, Taipei 11220, Taiwan
Che-Se Tung: Division of Medical Research & Education, Cheng Hsin General Hospital, Taipei 11220, Taiwan
Jen-Chun Wang: Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan
Wu-Chien Chien: Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan
Chi-Hsiang Chung: Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan
Chih-Yuan Lin: Department of Surgery, Division of Cardiovascular Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan
Shih-Hung Tsai: Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan

IJERPH, 2021, vol. 18, issue 8, 1-10

Abstract: Previous studies have indicated that patients with migraine have a higher prevalence of risk factors known to be associated with cardiovascular diseases. There are also shared epidemiology and molecular mechanisms between migraine and abdominal aortic aneurysm (AAA). We hypothesized that patients with migraine could have an increased risk of AAA. To test this hypothesis, we used the National Health Insurance Research Database (NHIRD) to evaluate whether associations exist between migraine and AAA. The data for this nationwide population-based retrospective cohort study were obtained from the NHIRD in Taiwan. The assessed study outcome was the cumulative incidence of AAA in patients with migraine during a 15-year follow-up period. Among the 1,936,512 patients from the NHIRD, 53,668 (2.77%) patients were identified as having been diagnosed with migraine. The patients with migraine had a significantly higher cumulative risk of 3.558 of developing an AAA 5 years after the index date compared with the patients without migraine. At the end of the 15-year follow-up period, a significantly higher incidence of AAA (0.98%) was observed in the patients with migraine than in those without migraine (0.24%). We revealed an association between the development of migraine and AAA.

Keywords: abdominal aortic aneurysm; migraine; cardiovascular diseases; National Health Insurance Research Database (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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