Relative Handgrip Strength as Marker of Cardiometabolic Risk in Women with Systemic Lupus Erythematosus

Sergio Sola-Rodríguez, José Antonio Vargas-Hitos, Blanca Gavilán-Carrera, Antonio Rosales-Castillo, José Mario Sabio, Alba Hernández-Martínez, Elena Martínez-Rosales, Norberto Ortego-Centeno and Alberto Soriano-Maldonado
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Sergio Sola-Rodríguez: Department of Education, Faculty of Education Sciences, University of Almería, 04120 Almería, Spain
José Antonio Vargas-Hitos: Systemic Autoimmune Diseases Unit, Department of Internal Medicine, Virgen de las Nieves University Hospital, 18014 Granada, Spain
Blanca Gavilán-Carrera: Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, 18071 Granada, Spain
Antonio Rosales-Castillo: Systemic Autoimmune Diseases Unit, Department of Internal Medicine, Virgen de las Nieves University Hospital, 18014 Granada, Spain
José Mario Sabio: Systemic Autoimmune Diseases Unit, Department of Internal Medicine, Virgen de las Nieves University Hospital, 18014 Granada, Spain
Alba Hernández-Martínez: Department of Education, Faculty of Education Sciences, University of Almería, 04120 Almería, Spain
Elena Martínez-Rosales: Department of Education, Faculty of Education Sciences, University of Almería, 04120 Almería, Spain
Norberto Ortego-Centeno: Systemic Autoimmune Diseases Unit, Department of Internal Medicine, “San Cecilio” University Hospital, 18016 Granada, Spain
Alberto Soriano-Maldonado: Department of Education, Faculty of Education Sciences, University of Almería, 04120 Almería, Spain

IJERPH, 2021, vol. 18, issue 9, 1-11

Abstract: This study aimed to examine the association of relative handgrip strength (rHGS) with cardiometabolic disease risk factors in women with systemic lupus erythematosus (SLE). Methods: Seventy-seven women with SLE (mean age 43.2, SD 13.8) and clinical stability during the previous six months were included. Handgrip strength was assessed with a digital dynamometer and rHGS was defined as absolute handgrip strength (aHGS) divided by body mass index (BMI). We measured blood pressure, markers of lipid and glucose metabolism, inflammation (high sensitivity C-reactive protein [hs-CRP]), arterial stiffness (pulse wave velocity [PWV]), and renal function. A clustered cardiometabolic risk index (z-score) was computed. Results: Pearson?s bivariate correlations revealed that higher rHGS was associated with lower systolic blood pressure (SBP), triglycerides, hs-CRP, PWV, and lower clustered cardiometabolic risk (r range = from ?0.43 to ?0.23; all p < 0.05). Multivariable linear regression analyses adjusted for age, disease activity (SLEDAI), and accrual damage (SDI) confirmed these results (all p < 0.05) except for triglycerides. Conclusions: The findings suggest that higher rHGS is significantly associated with lower cardiometabolic risk in women with SLE.

Keywords: autoimmune disease; cardiovascular risk; muscle strength; body mass index; metabolism; cardiovascular disease; lupus; risk factors (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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