A Randomized, Double-Blind, Placebo-Controlled Trial to Assess the Acidogenic Potential of Dental Biofilms through a Tablet Containing Weissella cibaria CMU

Mi-Sun Kang, Dong-Suk Lee, Myoungsuk Kim, Seung-Ah Lee and Seoul-Hee Nam
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Mi-Sun Kang: Research and Development Department, Research Institute, OraPharm Inc., Seoul 04782, Korea
Dong-Suk Lee: School of Nursing, Kangwon National University, Chuncheon 24341, Korea
Myoungsuk Kim: School of Nursing, Kangwon National University, Chuncheon 24341, Korea
Seung-Ah Lee: School of Nursing, Kangwon National University, Chuncheon 24341, Korea
Seoul-Hee Nam: Department of Dental Hygiene, College of Health Sciences, Kangwon National University, Samcheok 25949, Korea

IJERPH, 2021, vol. 18, issue 9, 1-10

Abstract: The possibility of preventing dental caries by taking probiotic bacterium Weissella cibaria ( W. cibaria ) CMU tablets to alter the pH of the dental plaque in the oral cavity was evaluated. A randomized, double-blind, placebo-controlled trial was performed on adults aged 20 years or older with 20 or more natural teeth. Ninety-two people underwent dental scaling before being randomly assigned to the experimental group ( n = 49) or the control group ( n = 43). Depending on the group they belonged to, W. cibaria CMU or the placebo was administered to them once daily for 8 weeks before bedtime. Twenty-four subjects were later excluded from the study because the week 8 dosing was not smoothly performed, for a final subject count of 68. The Cariview test was used to evaluate the amount of acid produced by the dental plaque to assess the risk of caries. The results showed that although there was no significant difference between the results of the two groups, the intake of the W. cibaria CMU tablets eliminated the risk of developing dental caries from acid production in the oral flora because the W. cibaria colonizes and lives in the dental plaque and the oral cavity and suppresses acids.

Keywords: Weissella cibaria; probiotics; dental biofilms; oral health; clinical study (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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