Physical Activity Regulates TNF? and IL-6 Expression to Counteract Inflammation in Cystic Fibrosis Patients

Ersilia Nigro, Rita Polito, Ausilia Elce, Giuseppe Signoriello, Paola Iacotucci, Vincenzo Carnovale, Monica Gelzo, Federica Zarrilli, Giuseppe Castaldo and Aurora Daniele
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Ersilia Nigro: Dipartimento di Scienze e Tecnologie Ambientali, Biologiche, Farmaceutiche, Università della Campania “Luigi Vanvitelli”, 81100 Caserta, Italy
Rita Polito: Dipartimento di Scienze e Tecnologie Ambientali, Biologiche, Farmaceutiche, Università della Campania “Luigi Vanvitelli”, 81100 Caserta, Italy
Ausilia Elce: CEINGE-Biotecnologie Avanzate Scarl, Via G. Salvatore 486, 80145 Napoli, Italy
Giuseppe Signoriello: Dipartimento di Salute Mentale e Fisica e Medicina Preventiva dell’Università degli Studi della Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Paola Iacotucci: Centro Regionale Fibrosi Cistica Adulti, Dipartimento di Scienze Mediche Traslazionali, Università degli Studi di Napoli Federico II, 80131 Napoli, Italy
Vincenzo Carnovale: Centro Regionale Fibrosi Cistica Adulti, Dipartimento di Scienze Mediche Traslazionali, Università degli Studi di Napoli Federico II, 80131 Napoli, Italy
Monica Gelzo: CEINGE-Biotecnologie Avanzate Scarl, Via G. Salvatore 486, 80145 Napoli, Italy
Federica Zarrilli: CEINGE-Biotecnologie Avanzate Scarl, Via G. Salvatore 486, 80145 Napoli, Italy
Giuseppe Castaldo: CEINGE-Biotecnologie Avanzate Scarl, Via G. Salvatore 486, 80145 Napoli, Italy
Aurora Daniele: Dipartimento di Scienze e Tecnologie Ambientali, Biologiche, Farmaceutiche, Università della Campania “Luigi Vanvitelli”, 81100 Caserta, Italy

IJERPH, 2021, vol. 18, issue 9, 1-8

Abstract: Background: Cystic fibrosis (CF) is one of the most common inherited diseases. It is characterised by a severe decline in pulmonary function associated with metabolic perturbations and an increased production of inflammatory cytokines. The key role of physical activity (PA) in improving the health status of CF patients and reducing lung function decline has recently been demonstrated. This study evaluated interleukin-6 (IL-6) and tumour necrosis factor ? (TNF?) expression in two subgroups of CF patients classified based on PA. Methods: We selected 85 CF patients; half of them regularly undertook supervised PA in the three years leading up to the study and half of them were not physically active. Patients were analysed for serum IL-6 and TNF? levels using enzyme-linked immunosorbent assays. Results: We found that the expression levels of IL-6 and TNF? differed in terms of their regulation by PA. In particular, TNF? levels negatively correlated with FEV1% decrease/year and FEV1% decrease ( p = 0.023 and p = 0.02, respectively), and positively correlated with serum fasting glucose ( p = 0.019) in PA CF patients. In contrast, in the NPA subgroup, TNF? levels were positively correlated with IL-6 ( p = 0.001) and negatively correlated with adiponectin ( p = 0.000). In addition, multiple logistic regression analysis confirmed that PA is an independent modulator of the inflammatory state. Conclusions: PA modulates inflammatory processes in CF patients by regulating the secretion of pro-inflammatory cytokines and thus ameliorating lung function. Our data show that PA is a useful complementary strategy in the management of CF and that TNF? may be a marker of these effects of PA.

Keywords: cystic fibrosis; physical activity; TNF?; IL6; inflammation (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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