Prenatal Exposure to Cigarette Smoke and Anogenital Distance at 4 Years in the INMA-Asturias Cohort

Miguel García-Villarino, Rocío Fernández-Iglesias, Isolina Riaño-Galán, Cristina Rodríguez-Dehli, Izaro Babarro, Ana Fernández-Somoano and Adonina Tardón
Additional contact information
Miguel García-Villarino: Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Monforte de Lemos Avenue 3-5, 28029 Madrid, Spain
Rocío Fernández-Iglesias: Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Monforte de Lemos Avenue 3-5, 28029 Madrid, Spain
Isolina Riaño-Galán: Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Monforte de Lemos Avenue 3-5, 28029 Madrid, Spain
Cristina Rodríguez-Dehli: Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Roma Avenue s/n., 33001 Oviedo, Spain
Izaro Babarro: Faculty of Psychology, University of the Basque Country, 20018 Donostia/San Sebastian, Spain
Ana Fernández-Somoano: Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Monforte de Lemos Avenue 3-5, 28029 Madrid, Spain
Adonina Tardón: Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Monforte de Lemos Avenue 3-5, 28029 Madrid, Spain

IJERPH, 2021, vol. 18, issue 9, 1-14

Abstract: Smoking by women is associated with adverse pregnancy outcomes such as spontaneous abortion, preterm delivery, low birth weight, infertility, and prolonged time to pregnancy. Anogenital distance (AGD) is a sensitive biomarker of prenatal androgen and antiandrogen exposure. We investigated the effect of smoking and passive smoke exposure during pregnancy on anogenital distance in offspring at 4 years in the INMA-Asturias cohort (Spain). Women were interviewed during pregnancy to collect information on tobacco consumption, and anogenital distance was measured in 381 children: Anoscrotal distance in boys and anofourchetal distance in girls. We also measured maternal urinary cotinine levels at 32 weeks of pregnancy. We constructed linear regression models to analyze the association between prenatal smoke exposure and anogenital distance and adjusted the models by relevant covariates. Reported prenatal smoke exposure was associated with statistically significant increased anogenital index (AGI), both at week 12 of pregnancy (? = 0.31, 95% confidence interval: 0.00, 0.63) and at week 32 of pregnancy (? = 0.31, 95% confidence interval: 0.00, 0.63) in male children, suggesting altered androgenic signaling.

Keywords: anogenital distance; maternal cigarette smoking; tobacco smoking; endocrine-disrupting chemicals (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/18/9/4774/pdf (application/pdf)
https://www.mdpi.com/1660-4601/18/9/4774/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:18:y:2021:i:9:p:4774-:d:546568

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().